PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Kalax.0384s0025.2.p
Organism
Kalanchoe marnieriana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe
Family E2F/DP
Protein Properties Length: 380aa    MW: 42098.9 Da    PI: 4.5653
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Kalax.0384s0025.2.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.8e-2742107171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                          r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Kalax.0384s0025.2.p  42 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 107
                          6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.3E-2939109IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.72E-1742105IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-3442107IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.7E-2444107IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146604.68E-47122224No hitNo description
SuperFamilySSF1440741.67E-33122224No hitNo description
PfamPF164219.3E-34123222IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 380 aa     Download sequence    Send to blast
MSAKGGRVYN KSKGSKGNKA ATQTPMLTAG SPSALTPAGN CRYDSSLGLL TKKFINLIKH  60
AEDGILDLNK AAETLEVQKR RIYDITNVLE GIGLIEKKLK NRIRWKGLDV SQPGGVETDV  120
FSLQTDVENL NLEEQKLDDE IREMQERLRY LSEDENNQKW LFVTEDDIKS LPCFQNETLI  180
AIKAPHGTTL EVPDPDEAAD YPQRRYRIVL RSTMGPIDVY LVSQFEEKFE DMNGAEQSVN  240
CPVASTSRSV ENSGTHATNK ESMGNDITGQ AQDARRLPSD RQMNDNGSDD FVSGIMKIVP  300
DVNTDTDYWF LSDAELSVTE LWHSETGIGN HLEDMHHANY EIGDTSIPQP QTPPSGVTDI  360
PPPSVNSTPR LVCSPKTIE*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-2437108274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008243467.10.0PREDICTED: transcription factor E2FA
SwissprotQ9FNY01e-138E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2P5D9W80.0A0A2P5D9W8_PARAD; E2F Family
STRINGXP_008243467.10.0(Prunus mume)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-141E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]