PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lj4g3v1561700.1
Organism
Lotus japonicus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Loteae; Lotus
Family E2F/DP
Protein Properties Length: 383aa    MW: 42947.1 Da    PI: 9.6185
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lj4g3v1561700.1genomeKazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP75.94e-242287171
          E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                     rk+ksL+ll+++fl+l+++ +   + l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Lj4g3v1561700.1 22 RKQKSLGLLCTNFLSLYNRDNIHLIGLDDAASRL---GV--ERRRIYDIVNVLESIGVLSRKAKNQYTWKG 87
                     79*****************999************...**..****************************98 PP
2E2F_TDP75.55.2e-24156236171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                      r+eksL lltq+f+kl+ +s+ ++++l+++ak L+ +      +++k+RR+YDi+NVL+++ liek     ++k+++rw g
  Lj4g3v1561700.1 156 RREKSLALLTQNFVKLFLCSNVEMISLDDAAKLLLGDahntsIMRTKVRRLYDIANVLSSMSLIEKthtkdTRKPAFRWLG 236
                      689**************************************999***********************999999******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.1E-261888IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.33E-162185IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-282287IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-202387IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.6E-24152238IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.6E-32156236IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.4E-19158236IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.83E-13158237IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 383 aa     Download sequence    Send to blast
MAAAAPPSDP AAASSKHHTY NRKQKSLGLL CTNFLSLYNR DNIHLIGLDD AASRLGVERR  60
RIYDIVNVLE SIGVLSRKAK NQYTWKGFRA IPLALQELKD EGLREKSSDF DGGNDSGKVS  120
DDEDDEEGFG NPSTGSQNEK SMSNSTLPRS MKNDNRREKS LALLTQNFVK LFLCSNVEMI  180
SLDDAAKLLL GDAHNTSIMR TKVRRLYDIA NVLSSMSLIE KTHTKDTRKP AFRWLGLKGR  240
TGNESVSTSN LNESRKRAFG TDVTNISFAR NRTDLFMNGD FGQNSKKQKI LENDGVLSQA  300
DKSNLQQDTK QTYQFGPFAP AYVSKAGNSE NSNVKQVHDW ESLATAHCPR YQNQALKELF  360
SHYMEAWRSW YSEVAGKRSI QTL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A8e-42222284228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapLj4g3v1561700.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAP0097160.0AP009716.1 Lotus japonicus genomic DNA, chromosome 4, clone: LjT30K03, TM1793, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027368833.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-127E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1S2YRL50.0A0A1S2YRL5_CICAR; E2F transcription factor-like E2FE isoform X1
STRINGXP_004508820.10.0(Cicer arietinum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-119DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]