PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa000449

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

C2H2

Protein Properties

Length: 243aa MW: 27893.6 Da PI: 8.4145

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Lsa#S18780370	PU_ref	Unigene	View CDS
PUT-187a-Lactuca_sativa-52249	PU_unref	plantGDB	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	13.2	0.00027	80	102	3	23
ET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 3 Cp..dCgksFsrksnLkrHirtH 23 C+ Cgk+F + L++H +H Lsa000449 80 CSyeGCGKTFIDAGALRKHSHVH 102 77779**************8776 PP
2	zf-C2H2	16	3.3e-05	107	131	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 ++C+ +Cgk F ++s LkrH H Lsa000449 107 FVCHyeNCGKKFLDSSKLKRHFLIH 131 89*******************8877 PP
3	zf-C2H2	21.5	6.2e-07	137	161	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 + Cp Cgk Fs nL++H++tH Lsa000449 137 FICPheGCGKAFSLDFNLRSHMKTH 161 78**********************9 PP
4	zf-C2H2	15.9	3.7e-05	167	191	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 + Cp Cgk++ + + Lk+Hi++H Lsa000449 167 HICPyqECGKRYAHEYKLKNHIMSH 191 68**********************6 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	3.3E-14	73	104	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	10.783	78	107	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.0029	78	102	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	80	102	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	3.9E-8	81	131	No hit	No description
Gene3D	G3DSA:3.30.160.60	5.4E-14	105	127	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.02	107	131	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	13.983	107	136	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	109	131	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	3.29E-14	118	170	No hit	No description
Gene3D	G3DSA:3.30.160.60	5.5E-20	128	163	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	12.591	137	166	IPR007087	Zinc finger, C2H2
SMART	SM00355	3.9E-4	137	161	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	139	161	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	9.5E-8	164	191	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.063	167	191	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	9.827	167	196	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	169	192	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 243 aa Download sequence Send to blast
XMEHQSFHNL FERRPFIKSK TPAVKWFKEW VPQDVVATGG KCYVLKWVTE AQMNAMKEKP 60 VDSEAVEPEP EPTTEVLFLC SYEGCGKTFI DAGALRKHSH VHGERQFVCH YENCGKKFLD 120 SSKLKRHFLI HTGERDFICP HEGCGKAFSL DFNLRSHMKT HSQENYHICP YQECGKRYAH 180 EYKLKNHIMS HHEKQGNNTN MVEVPPPPPP KYVHVQEKPP PKPPKAAAAA TYATAVSDRP 240 YAC

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ubd_C	7e-37	71	197	2	123	PROTEIN (YY1 ZINC FINGER DOMAIN)
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Functional Description ? help Back to Top
Source	Description
UniProt	Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269\|PubMed:22508367, ECO:0000269\|PubMed:24451981, ECO:0000269\|PubMed:26961720}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269\|PubMed:26961720}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023762639.1	1e-160	LOW QUALITY PROTEIN: zinc finger transcription factor YY1-like
Swissprot	Q2V3L3	1e-105	YY1_ARATH; Zinc finger transcription factor YY1
TrEMBL	A0A2J6LGA6	1e-150	A0A2J6LGA6_LACSA; Uncharacterized protein
STRING	Migut.B00804.1.p	1e-124	(Erythranthe guttata)

Publications ? help Back to Top
Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4. DNA Res., 2001. 8(6): p. 285-90 [PMID:11853315] Li T,Wu XY,Li H,Song JH,Liu JY A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network. Mol Plant, 2016. 9(5): p. 650-661 [PMID:26961720] Wu XY,Li T A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response. Front Plant Sci, 2017. 8: p. 323 [PMID:28348572]