PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa000994
Organism
Lactuca sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family WRKY
Protein Properties Length: 486aa    MW: 53693.7 Da    PI: 8.7154
Description WRKY family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PUT-187a-Lactuca_sativa-10566PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRKY95.83e-30231287259
                --SS-EEEEEEE--TT-SS-EEEEEE-STT---EEEEEE-SSSTTEEEEEEES--SS- CS
       WRKY   2 dDgynWrKYGqKevkgsefprsYYrCtsagCpvkkkversaedpkvveitYegeHnhe 59 
                +DgynWrKYGqK+vk se+prsYY+Ct+a+Cpvkkkv +s  d+++ +i+Y+g+Hnh+
  Lsa000994 231 NDGYNWRKYGQKQVKASEHPRSYYKCTHANCPVKKKVGQSF-DGHISDIVYKGQHNHD 287
                8****************************************.***************7 PP
2WRKY1048.4e-33382440159
                ---SS-EEEEEEE--TT-SS-EEEEEE-STT---EEEEEE-SSSTTEEEEEEES--SS- CS
       WRKY   1 ldDgynWrKYGqKevkgsefprsYYrCtsagCpvkkkversaedpkvveitYegeHnhe 59 
                ldDg++WrKYGqK+vkg+++prsYY+Ct+agC+v+k+ver+ +dpk v++tYeg+Hnh+
  Lsa000994 382 LDDGFKWRKYGQKVVKGNTNPRSYYKCTYAGCNVRKHVERAPSDPKSVVTTYEGKHNHD 440
                59********************************************************7 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5081121.781225289IPR003657WRKY domain
SuperFamilySSF1182906.54E-24227289IPR003657WRKY domain
Gene3DG3DSA:2.20.25.806.3E-27229289IPR003657WRKY domain
SMARTSM007745.5E-32230288IPR003657WRKY domain
PfamPF031061.8E-23231287IPR003657WRKY domain
Gene3DG3DSA:2.20.25.803.8E-35368442IPR003657WRKY domain
SuperFamilySSF1182901.19E-28374442IPR003657WRKY domain
PROSITE profilePS5081136.15377442IPR003657WRKY domain
SMARTSM007749.8E-38382441IPR003657WRKY domain
PfamPF031062.7E-25383440IPR003657WRKY domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 486 aa     Download sequence    Send to blast
MAETNGGSAA AAPPPQQQRR VPPMIALPPQ TSFETLFTGG PGPGFSPGPM TLISNFFSDH  60
NTDIDCRSFS QLLAGAMASP ASQIPPTSMF DDCSSSKQPD SEKKQGGFKQ NRPMDLVIAQ  120
SPSGFMFPST FSPSGLLNSP GFFSPLQSPF GMSHQQALAH VTAQAALSQS YFNQIQPENQ  180
NKSSQSHEEP QIVNTKSDLS DSQIGSPDDV SFSQSDISEP RHVITAPTDT NDGYNWRKYG  240
QKQVKASEHP RSYYKCTHAN CPVKKKVGQS FDGHISDIVY KGQHNHDPPL VNKRGKESAD  300
VSKPNNYQFE TRVVEAAAQP ARDIPRSNEL IRIDESDDEP NPKRRNTEVG PVAAPVESNF  360
SHNKMVAEPK IVVQTRSEVD LLDDGFKWRK YGQKVVKGNT NPRSYYKCTY AGCNVRKHVE  420
RAPSDPKSVV TTYEGKHNHD IPVSRHRAYN TEKGTNVKSS SQRKETKFGN NERPVLLQMK  480
EEKITA
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1wj2_A7e-36231442877Probable WRKY transcription factor 4
2lex_A7e-36231442877Probable WRKY transcription factor 4
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds specifically to the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Has a positive role in resistance to necrotrophic pathogens (e.g. Botrytis cinerea), but a negative effect on plant resistance to biotrophic pathogens (e.g. Pseudomonas syringae). {ECO:0000269|PubMed:18570649, ECO:0000269|PubMed:22219184}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By biotic and abiotic stresses such as pathogen infection (e.g. Botrytis cinerea and Pseudomonas syringae), salicylic acid (SA), jasmonic acid (JA), ethylene (ACC), liquid infiltration or spraying, and strongly during leaf senescence. {ECO:0000269|PubMed:11449049, ECO:0000269|PubMed:11722756, ECO:0000269|PubMed:18570649}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023745735.10.0probable WRKY transcription factor 3
SwissprotQ9XI901e-115WRKY4_ARATH; Probable WRKY transcription factor 4
TrEMBLA0A2J6M9Z60.0A0A2J6M9Z6_LACSA; Uncharacterized protein
STRINGXP_002530024.11e-152(Ricinus communis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G13960.11e-110WRKY DNA-binding protein 4
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Aamir M, et al.
    Structural and Functional Insights into WRKY3 and WRKY4 Transcription Factors to Unravel the WRKY-DNA (W-Box) Complex Interaction in Tomato (Solanum lycopersicum L.). A Computational Approach.
    Front Plant Sci, 2017. 8: p. 819
    [PMID:28611792]