PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa002594

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

E2F/DP

Protein Properties

Length: 442aa MW: 49123.9 Da PI: 4.6023

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Lsa#S58688602	PU_ref	Unigene	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.7	1.7e-27	141	206	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l+ ++e+giv+ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg Lsa002594 141 RYDSSLGLLTKKFINLITHAEDGIVDLNNAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 206 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	9.1E-29	139	208	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	7.9E-34	141	206	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	4.17E-17	141	204	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	6.6E-24	143	206	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	6.79E-45	217	323	No hit	No description
SuperFamily	SSF144074	8.11E-33	218	323	No hit	No description
Pfam	PF16421	4.1E-33	222	321	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 442 aa Download sequence Send to blast
MSEARVSNLH EAPSPPPASA GVGGRGPIPH PMRRHLSLYS TKPPFIPSDD YHRFSTGNDG 60 KRIATTADQD SEVIIVRSPQ VKRKLGTSHY NEVASTVNSP VCTPVSAKGG KVNSRSKGTK 120 SNKPIPQSPL HISGSPSPAT RYDSSLGLLT KKFINLITHA EDGIVDLNNA ADTLEVQKRR 180 IYDITNVLEG IGLIEKKLKN RIRWKGLDSS KPEELEDDVT LLQAEVQRLS MEEQRLDESI 240 REMQERMREF SEDDNNQKWL FVTEDDIKSL PCFQNETLIA IKAPHGTTLE VPDPDEAVDY 300 PQRRYRIILR STMGPIDLYL VSQFEDMDGV EEQVPMQIAS SSGSNDNPTT EIAVVEPHPQ 360 NVNSSMTASP GRITKILPSD VDNEADYWLL SDREVPLTDM WNTDLVGDME WDGVDLLSEE 420 FGLADDVTTP PTSVNADITI QR

Sequence ? help Back to Top

Protein Sequence Length: 442 aa Download sequence Send to blast

MSEARVSNLH EAPSPPPASA GVGGRGPIPH PMRRHLSLYS TKPPFIPSDD YHRFSTGNDG  60
KRIATTADQD SEVIIVRSPQ VKRKLGTSHY NEVASTVNSP VCTPVSAKGG KVNSRSKGTK  120
SNKPIPQSPL HISGSPSPAT RYDSSLGLLT KKFINLITHA EDGIVDLNNA ADTLEVQKRR  180
IYDITNVLEG IGLIEKKLKN RIRWKGLDSS KPEELEDDVT LLQAEVQRLS MEEQRLDESI  240
REMQERMREF SEDDNNQKWL FVTEDDIKSL PCFQNETLIA IKAPHGTTLE VPDPDEAVDY  300
PQRRYRIILR STMGPIDLYL VSQFEDMDGV EEQVPMQIAS SSGSNDNPTT EIAVVEPHPQ  360
NVNSSMTASP GRITKILPSD VDNEADYWLL SDREVPLTDM WNTDLVGDME WDGVDLLSEE  420
FGLADDVTTP PTSVNADITI QR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-24	136	207	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023763658.1	0.0	transcription factor E2FA-like isoform X1
Swissprot	Q9FNY0	1e-138	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A2J6LE34	0.0	A0A2J6LE34_LACSA; Uncharacterized protein
STRING	VIT_08s0007g02510.t01	1e-179	(Vitis vinifera)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-142	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]