PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa003559
Organism
Lactuca sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family bHLH
Protein Properties Length: 529aa    MW: 58875 Da    PI: 5.7709
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PUT-187a-Lactuca_sativa-1623PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.87.9e-13374420455
                HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
        HLH   4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                +h e+Er+RR+++N++f  Lr ++P+ +      K++Ka+ L  A+ YI +Lq
  Lsa003559 374 NHVEAERQRREKLNQRFYALRAVVPNiS------KMDKASLLGDAIAYITDLQ 420
                799***********************66......*****************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142155.2E-5246234IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.806370419IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000835.71E-14373424No hitNo description
SuperFamilySSF474591.57E-18373434IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.6E-10374420IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.107.8E-18374432IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.2E-16376425IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 529 aa     Download sequence    Send to blast
MGGGNFNDEE KAIVAAVLGT RAFDYLIASS AGNECSLTSS ANDDNLQNKL SDLVDNPNSG  60
NFSWNYAIFW QISRSKSGDL VLVWGDGSCR EPREGEEFEI ARILSIRLED ENQQRIKKRV  120
LQNLHVLFGG LDEDNYAFGL DRVTDTEMFF LISMYFSFPQ GQGGPGKCFS SGNHLWYSDA  180
LRSTSDYCFR SNLSKSAGIQ TVVLIPTDVG VLEVGSIRSI PENMELLHSV RSSFSSNSNT  240
SLVSPLLSKL FNQDMGLSLR QPQFREKLTV RKPENHQPFP KIENPQILIS NSRNRITGSN  300
WAQFSTLQNP ATEMQIDFTA TATGAVSRPV SGDSEISDVE ASGREEMAIT ARTDDKRPRK  360
RGRKPANGRE EPLNHVEAER QRREKLNQRF YALRAVVPNI SKMDKASLLG DAIAYITDLQ  420
KKLREMESER SSTSSMDTPN NSVSNLQKIE IEAGEDEVTV RVTCPLDTHP MSKVIQGFKE  480
AGIRVLESKM GAGNDKVFHV FVVKSEGSEE LTKEKLMAVF SKESTSSLH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A5e-29368430264Transcription factor MYC2
5gnj_B5e-29368430264Transcription factor MYC2
5gnj_E5e-29368430264Transcription factor MYC2
5gnj_F5e-29368430264Transcription factor MYC2
5gnj_G5e-29368430264Transcription factor MYC2
5gnj_I5e-29368430264Transcription factor MYC2
5gnj_M5e-29368430264Transcription factor MYC2
5gnj_N5e-29368430264Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1355363KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that negatively regulates jasmonate (JA) signaling (PubMed:30610166). Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection (PubMed:30610166). Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by wounding, feeding with herbivorous insects, infection with the fungal pathogen Botrytis cinerea and infection with the bacterial pathogen Pseudomonas syringae pv tomato DC3000. {ECO:0000269|PubMed:30610166}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023740458.10.0transcription factor bHLH13-like
SwissprotA0A3Q7ELQ20.0MTB1_SOLLC; Transcription factor MTB1
TrEMBLA0A2J6MB670.0A0A2J6MB67_LACSA; Uncharacterized protein
STRINGPGSC0003DMT4000006520.0(Solanum tuberosum)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G01260.31e-159bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  3. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]