PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa004634
Organism
Lactuca sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family E2F/DP
Protein Properties Length: 364aa    MW: 40943.2 Da    PI: 8.3018
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Lsa#S58687789PU_refUnigeneView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP70.22.4e-222489171
    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
               rk+ksL+ll+++fl+l+++   ++v l+++a++L    v  +rRRiYDi+NVLe+++++ +k+kn + wkg
  Lsa004634 24 RKQKSLGLLCSNFLSLYNRDGVETVGLDDAASRL---GV--ERRRIYDIVNVLESVGVLVRKAKNTYYWKG 89
               79*****************999************...**..****************************98 PP
2E2F_TDP73.91.7e-23156236171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                rkeksL+llt++flkl+ ++++++++l+++ak L+ +      +++k+RR+YDi+NVL+++n iek     ++k+++rw g
  Lsa004634 156 RKEKSLGLLTKNFLKLFLCTPSDTLSLEDAAKILLGDarnpsLTRTKVRRLYDIANVLSSMNFIEKihhpeTRKPAFRWLG 236
                79***************************************98889*********************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-252090IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.72E-162487IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.3E-262489IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.4E-192589IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.5E-22153237IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.16E-12155225IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-31156236IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.0E-18157236IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 364 aa     Download sequence    Send to blast
MAIPSPSYSL ATKEPASGST TYCRKQKSLG LLCSNFLSLY NRDGVETVGL DDAASRLGVE  60
RRRIYDIVNV LESVGVLVRK AKNTYYWKGL GAIPKALEEL KEEGFRNNDE PIDCKSGKVW  120
EDDEDERFSN SSASFQEKAD PDSMHKSLGL FKSENRKEKS LGLLTKNFLK LFLCTPSDTL  180
SLEDAAKILL GDARNPSLTR TKVRRLYDIA NVLSSMNFIE KIHHPETRKP AFRWLGMRSQ  240
SQSQTDSKTG LVHPESKKRA FGTDLTNTNI SFKRTKTVLD VGVDQSVKLG VSHSGSDRLD  300
LKDPTGLVHG ESKEVKKSQD WESLASTHRP QYHNQALRDL FVHYMDAWSS WYSEVAEMDP  360
IEAV
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-35242284228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023733637.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-105E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2J6KFU80.0A0A2J6KFU8_LACSA; Uncharacterized protein
STRINGVIT_17s0000g07630.t011e-133(Vitis vinifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-107DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]