PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa006127

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

WRKY

Protein Properties

Length: 521aa MW: 56713.1 Da PI: 8.4768

Description

WRKY family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
PUT-187a-Lactuca_sativa-39427	PU_ref	plantGDB	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	WRKY	96.4	2e-30	260	318	2	59
--SS-EEEEEEE--TT-SS-EEEEEE-ST.T---EEEEEE-SSSTTEEEEEEES--SS- CS WRKY 2 dDgynWrKYGqKevkgsefprsYYrCtsa.gCpvkkkversaedpkvveitYegeHnhe 59 Dg++WrKYGqK+ kg+++pr+YYrCt+a gCpv+k+v+r+ +d++++++tYeg+Hnh+ Lsa006127 260 TDGCQWRKYGQKMAKGNPCPRAYYRCTMAvGCPVRKQVQRCVDDQTILITTYEGTHNHP 318 7*********************************************************7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:2.20.25.80	2.8E-33	244	320	IPR003657	WRKY domain
SuperFamily	SSF118290	7.98E-28	252	320	IPR003657	WRKY domain
PROSITE profile	PS50811	29.379	254	320	IPR003657	WRKY domain
SMART	SM00774	1.1E-36	259	319	IPR003657	WRKY domain
Pfam	PF03106	1.8E-26	261	318	IPR003657	WRKY domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 521 aa Download sequence Send to blast
MGKAGWGLTL DTSEPLELLS PRWNFPVKPA MFSGVSPKMT DEKNSNRKVL SEVDFFSTSK 60 SNDDQIVVKK ENISHATELD VNTGLHLHTT NSDQSSVDDG VSSSGDDKQA KNKLTILQVE 120 LEKMNTENQR LRGMLSQVSN NYTALQMHIA NEIQKQQNSS KQIVLQDQKP VPQQLNHLPP 180 TSHDSSSSEE RTQSGSTLNA IELSKNGKRT GRENTPDSDT WVSNKIPKLN TTKNIEQAND 240 PTMRKARVSV RARSEAPMIT DGCQWRKYGQ KMAKGNPCPR AYYRCTMAVG CPVRKQVQRC 300 VDDQTILITT YEGTHNHPLP PAALAMASTT SAAASMLLSG SISSADGLMN QNVLARSILP 360 NASSIATISA SAPFPTITLD LTHNPNQYQR INNSNQFQVP HHMSSQNFQP GMAIPLQSIP 420 GNGDVGVYNQ SRFSGLQLSH DMESNQLRAH HVTPPQFKGQ VNTSFSDSLS AATAAITADP 480 NFTAALAAAI SSIMSGGNTT TTTTTSHTTT NNHKDSNHYG N

Sequence ? help Back to Top

Protein Sequence Length: 521 aa Download sequence Send to blast

MGKAGWGLTL DTSEPLELLS PRWNFPVKPA MFSGVSPKMT DEKNSNRKVL SEVDFFSTSK  60
SNDDQIVVKK ENISHATELD VNTGLHLHTT NSDQSSVDDG VSSSGDDKQA KNKLTILQVE  120
LEKMNTENQR LRGMLSQVSN NYTALQMHIA NEIQKQQNSS KQIVLQDQKP VPQQLNHLPP  180
TSHDSSSSEE RTQSGSTLNA IELSKNGKRT GRENTPDSDT WVSNKIPKLN TTKNIEQAND  240
PTMRKARVSV RARSEAPMIT DGCQWRKYGQ KMAKGNPCPR AYYRCTMAVG CPVRKQVQRC  300
VDDQTILITT YEGTHNHPLP PAALAMASTT SAAASMLLSG SISSADGLMN QNVLARSILP  360
NASSIATISA SAPFPTITLD LTHNPNQYQR INNSNQFQVP HHMSSQNFQP GMAIPLQSIP  420
GNGDVGVYNQ SRFSGLQLSH DMESNQLRAH HVTPPQFKGQ VNTSFSDSLS AATAAITADP  480
NFTAALAAAI SSIMSGGNTT TTTTTSHTTT NNHKDSNHYG N

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2ayd_A	3e-21	246	322	1	76	WRKY transcription factor 1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in the control of processes related to senescence and pathogen defense (PubMed:12000796). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:12000796). Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes (PubMed:12000796). Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression (PubMed:25733771). {ECO:0000269\|PubMed:12000796, ECO:0000269\|PubMed:25733771}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By salicylic acid, ethylene, jasmonic acid, pathogens, wounding and strongly during leaf senescence. {ECO:0000269\|PubMed:11449049, ECO:0000269\|PubMed:11722756}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023759449.1	0.0	WRKY transcription factor 6-like
Swissprot	Q9C519	1e-140	WRKY6_ARATH; WRKY transcription factor 6
TrEMBL	A0A2J6LNM8	0.0	A0A2J6LNM8_LACSA; Uncharacterized protein
STRING	EOY28756	1e-170	(Theobroma cacao)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G62300.1	1e-107	WRKY family protein

Publications ? help Back to Top
Zhou F, et al. High humidity suppresses ssi4-mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression. Plant J., 2004. 39(6): p. 920-32 [PMID:15341634] Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P An extracellular subtilase switch for immune priming in Arabidopsis. PLoS Pathog., 2013. 9(6): p. e1003445 [PMID:23818851] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Singh V,Roy S,Singh D,Nandi AK Arabidopsis flowering locus D influences systemic-acquired-resistance- induced expression and histone modifications of WRKY genes. J. Biosci., 2014. 39(1): p. 119-26 [PMID:24499796] Ali MA,Wieczorek K,Kreil DP,Bohlmann H The beet cyst nematode Heterodera schachtii modulates the expression of WRKY transcription factors in syncytia to favour its development in Arabidopsis roots. PLoS ONE, 2014. 9(7): p. e102360 [PMID:25033038] Chai J,Liu J,Zhou J,Xing D Mitogen-activated protein kinase 6 regulates NPR1 gene expression and activation during leaf senescence induced by salicylic acid. J. Exp. Bot., 2014. 65(22): p. 6513-28 [PMID:25210078] Vermeirssen V,De Clercq I,Van Parys T,Van Breusegem F,Van de Peer Y Arabidopsis ensemble reverse-engineered gene regulatory network discloses interconnected transcription factors in oxidative stress. Plant Cell, 2014. 26(12): p. 4656-79 [PMID:25549671] Xiao D, et al. SENESCENCE-SUPPRESSED PROTEIN PHOSPHATASE Directly Interacts with the Cytoplasmic Domain of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE and Negatively Regulates Leaf Senescence in Arabidopsis. Plant Physiol., 2015. 169(2): p. 1275-91 [PMID:26304848] Bakshi M, et al. WRKY6 restricts Piriformospora indica-stimulated and phosphate-induced root development in Arabidopsis. BMC Plant Biol., 2015. 15: p. 305 [PMID:26718529] Huang Y,Feng CZ,Ye Q,Wu WH,Chen YF Arabidopsis WRKY6 Transcription Factor Acts as a Positive Regulator of Abscisic Acid Signaling during Seed Germination and Early Seedling Development. PLoS Genet., 2016. 12(2): p. e1005833 [PMID:26829043] Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P Correction: An Extracellular Subtilase Switch for Immune Priming in Arabidopsis. PLoS Pathog., 2016. 12(11): p. e1006003 [PMID:27806116] Li H, et al. BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis. Mol Plant, 2017. 10(4): p. 545-559 [PMID:28089951] Stetter MG,Benz M,Ludewig U Increased root hair density by loss of WRKY6 in Arabidopsis thaliana. PeerJ, 2017. 5: p. e2891 [PMID:28149680] Zhou X, et al. StMYB44 negatively regulates phosphate transport by suppressing expression of PHOSPHATE1 in potato. J. Exp. Bot., 2017. 68(5): p. 1265-1281 [PMID:28338870] Bakshi M, et al. Piriformospora indica Reprograms Gene Expression in Arabidopsis Phosphate Metabolism Mutants But Does Not Compensate for Phosphate Limitation. Front Microbiol, 2017. 8: p. 1262 [PMID:28747898] Zhang Y, et al. DELLA proteins negatively regulate dark-induced senescence and chlorophyll degradation in Arabidopsis through interaction with the transcription factor WRKY6. Plant Cell Rep., 2018. 37(7): p. 981-992 [PMID:29574486]