PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa006959

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

NAC

Protein Properties

Length: 373aa MW: 42475.8 Da PI: 6.4343

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
PUT-187a-Lactuca_sativa-26797	PU_ref	plantGDB	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	164.9	2.8e-51	23	150	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp.k.kvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskkge 98 l+pGfrFhPtdeelv +yL++kv gk++++ ++++e+d+yk+ePw+L ++++ ewyfFs+ d+ky +g r nrat +gyWkatgkd++v + k+e Lsa006959 23 LAPGFRFHPTDEELVRYYLRRKVCGKPFRF-QAVSEIDVYKSEPWELAdFsPWNSRDLEWYFFSPVDRKYGNGCRLNRATGQGYWKATGKDRAVRH-KSE 120 579***********************99.88**********84235566778**********************************.999 PP NAM 99 lvglkktLvfykgrapkgektdWvmheyrl 128 ++g+kktLvf++grap+g++t+Wvmheyrl Lsa006959 121 TIGMKKTLVFHSGRAPDGKRTNWVMHEYRL 150 **************************97 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	4.05E-61	21	173	IPR003441	NAC domain
PROSITE profile	PS51005	57.568	23	173	IPR003441	NAC domain
Pfam	PF02365	1.3E-28	25	150	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 373 aa Download sequence Send to blast
MGHELMVVAP PPPPPPPPPP TSLAPGFRFH PTDEELVRYY LRRKVCGKPF RFQAVSEIDV 60 YKSEPWELAD FSPWNSRDLE WYFFSPVDRK YGNGCRLNRA TGQGYWKATG KDRAVRHKSE 120 TIGMKKTLVF HSGRAPDGKR TNWVMHEYRL LDQELQRAGV AQDAFVLCRI FQKSGLGPPN 180 GDRYAPFVEE EWNHDADADV DAALFVPEDE TCVERNEIVE NNPKTIPFVC KRERSQDSPS 240 NSEPKLETFS LFHNKRLKPN DPNSNNANGS EDSTTTSQDP RATTTTTTLV EFPLLKETHH 300 PTTPKSFDAS TLEKSVPPGY LKFISNLENE ILNVSMEKET LKIEVMRAQA MINILQSRID 360 DLSKENNELR KGV

Sequence ? help Back to Top

Protein Sequence Length: 373 aa Download sequence Send to blast

MGHELMVVAP PPPPPPPPPP TSLAPGFRFH PTDEELVRYY LRRKVCGKPF RFQAVSEIDV  60
YKSEPWELAD FSPWNSRDLE WYFFSPVDRK YGNGCRLNRA TGQGYWKATG KDRAVRHKSE  120
TIGMKKTLVF HSGRAPDGKR TNWVMHEYRL LDQELQRAGV AQDAFVLCRI FQKSGLGPPN  180
GDRYAPFVEE EWNHDADADV DAALFVPEDE TCVERNEIVE NNPKTIPFVC KRERSQDSPS  240
NSEPKLETFS LFHNKRLKPN DPNSNNANGS EDSTTTSQDP RATTTTTTLV EFPLLKETHH  300
PTTPKSFDAS TLEKSVPPGY LKFISNLENE ILNVSMEKET LKIEVMRAQA MINILQSRID  360
DLSKENNELR KGV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3swm_A	2e-51	17	173	14	168	NAC domain-containing protein 19
3swm_B	2e-51	17	173	14	168	NAC domain-containing protein 19
3swm_C	2e-51	17	173	14	168	NAC domain-containing protein 19
3swm_D	2e-51	17	173	14	168	NAC domain-containing protein 19
3swp_A	2e-51	17	173	14	168	NAC domain-containing protein 19
3swp_B	2e-51	17	173	14	168	NAC domain-containing protein 19
3swp_C	2e-51	17	173	14	168	NAC domain-containing protein 19
3swp_D	2e-51	17	173	14	168	NAC domain-containing protein 19
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional repressor that binds to the motif 5'-(C/T)A(C/A)G-3' in the promoter of target genes (PubMed:25578968). Binds also to the 5'-CTTGNNNNNCAAG-3' consensus sequence in chromatin (PubMed:26617990). Can bind to the mitochondrial dysfunction motif (MDM) present in the upstream regions of mitochondrial dysfunction stimulon (MDS) genes involved in mitochondrial retrograde regulation (MRR) (PubMed:24045019). Together with NAC051/NAC052 and JMJ14, regulates gene expression and flowering time by associating with the histone demethylase JMJ14, probably by the promotion of RNA-mediated gene silencing (PubMed:25578968, PubMed:26617990). {ECO:0000269\|PubMed:24045019, ECO:0000269\|PubMed:25578968, ECO:0000269\|PubMed:26617990}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023757039.1	0.0	NAC domain containing protein 50-like
Swissprot	Q9SQX9	2e-92	NAC50_ARATH; NAC domain containing protein 50
TrEMBL	A0A2J6LT40	0.0	A0A2J6LT40_LACSA; Uncharacterized protein
STRING	XP_009619467.1	0.0	(Nicotiana tomentosiformis)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G10480.2	2e-91	NAC domain containing protein 50

Publications ? help Back to Top
Zhang S, et al. C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association. Cell Discov, 2019. [PMID:26617990]