PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa007753

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

NAC

Protein Properties

Length: 373aa MW: 42334.6 Da PI: 5.1175

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Lsa#S58685143	PU_ref	Unigene	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	158.3	3.1e-49	23	149	2	128
NAM 2 ppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp..kkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskkgel 99 +pGfrFhPtdeelv +yL++kv gk+++ ++++evdiyk+ePw+L ++vk+++ ewyf s++dkkya+++r +r+t++g+Wk+tgk++e+ + k+e+ Lsa007753 23 APGFRFHPTDEELVRYYLRRKVCGKPFQS-QMVPEVDIYKSEPWELAdyTSVKSRDLEWYFISPTDKKYANSSRVKRSTERGFWKETGKTREINH-KSEK 120 79***********************99.89**********84347777888**********************************.9999 PP NAM 100 vglkktLvfykgrapkgektdWvmheyrl 128 +g kktLvf++grap+g +t+Wvmhey+l Lsa007753 121 IGQKKTLVFHSGRAPHGIRTNWVMHEYKL 149 *************************97 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	3.01E-55	20	172	IPR003441	NAC domain
PROSITE profile	PS51005	54.291	22	172	IPR003441	NAC domain
Pfam	PF02365	9.1E-26	24	149	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 373 aa Download sequence Send to blast
METGRVSMIV APPPPPLPPT FVAPGFRFHP TDEELVRYYL RRKVCGKPFQ SQMVPEVDIY 60 KSEPWELADY TSVKSRDLEW YFISPTDKKY ANSSRVKRST ERGFWKETGK TREINHKSEK 120 IGQKKTLVFH SGRAPHGIRT NWVMHEYKLL DQELQTAGVT QDAFVLCRIF EKSSIGPPNG 180 DWYGPFFEEE WDDEEALIVP VRDTMDDVEN DDETCAEGNN TMQMDAQMIP VVCKKVRSEN 240 GVLNSEPELE TLTLFHHKTS KGSDPNSSNA NGSHDSTMTS QGQTTTNLLS AVVTTIETHP 300 PATPPSFDAS ALEKSLPPEY MELIRDMENK IREVSMEKDA LKIELMQAQA TINVLHSHID 360 QLSKENTELK RGV

Sequence ? help Back to Top

Protein Sequence Length: 373 aa Download sequence Send to blast

METGRVSMIV APPPPPLPPT FVAPGFRFHP TDEELVRYYL RRKVCGKPFQ SQMVPEVDIY  60
KSEPWELADY TSVKSRDLEW YFISPTDKKY ANSSRVKRST ERGFWKETGK TREINHKSEK  120
IGQKKTLVFH SGRAPHGIRT NWVMHEYKLL DQELQTAGVT QDAFVLCRIF EKSSIGPPNG  180
DWYGPFFEEE WDDEEALIVP VRDTMDDVEN DDETCAEGNN TMQMDAQMIP VVCKKVRSEN  240
GVLNSEPELE TLTLFHHKTS KGSDPNSSNA NGSHDSTMTS QGQTTTNLLS AVVTTIETHP  300
PATPPSFDAS ALEKSLPPEY MELIRDMENK IREVSMEKDA LKIELMQAQA TINVLHSHID  360
QLSKENTELK RGV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3swm_A	2e-45	16	174	14	170	NAC domain-containing protein 19
3swm_B	2e-45	16	174	14	170	NAC domain-containing protein 19
3swm_C	2e-45	16	174	14	170	NAC domain-containing protein 19
3swm_D	2e-45	16	174	14	170	NAC domain-containing protein 19
3swp_A	2e-45	16	174	14	170	NAC domain-containing protein 19
3swp_B	2e-45	16	174	14	170	NAC domain-containing protein 19
3swp_C	2e-45	16	174	14	170	NAC domain-containing protein 19
3swp_D	2e-45	16	174	14	170	NAC domain-containing protein 19
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional repressor that binds to the motif 5'-(C/T)A(C/A)G-3' in the promoter of target genes (PubMed:25578968). Binds also to the 5'-CTTGNNNNNCAAG-3' consensus sequence in chromatin (PubMed:26617990). Can bind to the mitochondrial dysfunction motif (MDM) present in the upstream regions of mitochondrial dysfunction stimulon (MDS) genes involved in mitochondrial retrograde regulation (MRR) (PubMed:24045019). Together with NAC051/NAC052 and JMJ14, regulates gene expression and flowering time by associating with the histone demethylase JMJ14, probably by the promotion of RNA-mediated gene silencing (PubMed:25578968, PubMed:26617990). {ECO:0000269\|PubMed:24045019, ECO:0000269\|PubMed:25578968, ECO:0000269\|PubMed:26617990}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023770568.1	0.0	NAC domain containing protein 52-like
Swissprot	Q9SQX9	5e-83	NAC50_ARATH; NAC domain containing protein 50
TrEMBL	A0A2J6KZ04	0.0	A0A2J6KZ04_LACSA; Uncharacterized protein
STRING	XP_009619467.1	1e-150	(Nicotiana tomentosiformis)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G10480.2	4e-84	NAC domain containing protein 50

Publications ? help Back to Top
Zhang S, et al. C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association. Cell Discov, 2019. [PMID:26617990]