PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa008924
Organism
Lactuca sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family NAC
Protein Properties Length: 497aa    MW: 55497.2 Da    PI: 4.5522
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Lsa#S58692202PU_refUnigeneView CDS
PUT-187a-Lactuca_sativa-3738PU_unrefplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM1652.7e-51251512128
        NAM   2 ppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp..kkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskkgel 99 
                ppGfrFhPtdeelv +yLk+k+ g++l+l ++i evd+yk++P++Lp  +k+k+++++w+fFs+rd+ky++g r++rat +gyWkatgkd+ +++ k+  
  Lsa008924  25 PPGFRFHPTDEELVLYYLKRKICGRSLKL-DIIGEVDVYKWDPEELPgqSKLKSGDRQWFFFSPRDRKYPNGGRSSRATMNGYWKATGKDRIIKR-KSFP 122
                9****************************.99**************964489999************************************9999.999* PP

        NAM 100 vglkktLvfykgrapkgektdWvmheyrl 128
                vg+kktLv+y+grap+g++tdWvmhey++
  Lsa008924 123 VGIKKTLVYYQGRAPSGRRTDWVMHEYTM 151
                ***************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019416.93E-6021174IPR003441NAC domain
PROSITE profilePS5100555.85824174IPR003441NAC domain
PfamPF023654.5E-2725150IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 497 aa     Download sequence    Send to blast
MGSDLIEAVT VSKSKSAPSA GKCFPPGFRF HPTDEELVLY YLKRKICGRS LKLDIIGEVD  60
VYKWDPEELP GQSKLKSGDR QWFFFSPRDR KYPNGGRSSR ATMNGYWKAT GKDRIIKRKS  120
FPVGIKKTLV YYQGRAPSGR RTDWVMHEYT MDEEELKRCP FTQEHYVLYK IFKKSGPGPK  180
NGEQYGAPFV EEEWSDDEDC VDLDAFLVQK RNLIPIPIAV DDVKVVGEEE EENVFTNDIV  240
EFLNKIIDEP EIPPQVPEVK ETGNCFMESC GDLKDFLELD DLVGPQPGIA DSIPEFGSLA  300
EFDLYHDSIT RFVEYGPENS GLGSEVLSHG NDEFQISCDL WDYNNHGDSS ITTTTTTQTT  360
QQAISYPSSG VLMEENPEFY TNQCPENDVD NGNGTGSWFS TALWSFVDSI PTTPASASEG  420
SALVNKAFER MSSFSRGRNV NLAAAAASAA NGSGLKRLEK PSSRGRGIVF FSVLGVLFAI  480
LWVFVGSSME LLGRCIW
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3swm_A1e-471818014174NAC domain-containing protein 19
3swm_B1e-471818014174NAC domain-containing protein 19
3swm_C1e-471818014174NAC domain-containing protein 19
3swm_D1e-471818014174NAC domain-containing protein 19
3swp_A1e-471818014174NAC domain-containing protein 19
3swp_B1e-471818014174NAC domain-containing protein 19
3swp_C1e-471818014174NAC domain-containing protein 19
3swp_D1e-471818014174NAC domain-containing protein 19
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator that acts as positive regulator of AOX1A during mitochondrial dysfunction. Binds directly to AOX1A promoter. Mediates mitochondrial retrograde signaling. {ECO:0000269|PubMed:24045017}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cold and drought stresses. {ECO:0000269|PubMed:17158162}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023772241.10.0NAC domain-containing protein 17-like
SwissprotQ9XIC51e-125NAC17_ARATH; NAC domain-containing protein 17
TrEMBLA0A2J6KV890.0A0A2J6KV89_LACSA; Uncharacterized protein
STRINGXP_009339761.11e-138(Pyrus x bretschneideri)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G34190.11e-121NAC domain containing protein 17
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Van Aken O, et al.
    Mitochondrial and Chloroplast Stress Responses Are Modulated in Distinct Touch and Chemical Inhibition Phases.
    Plant Physiol., 2016. 171(3): p. 2150-65
    [PMID:27208304]
  3. Van Aken O,Ford E,Lister R,Huang S,Millar AH
    Retrograde signalling caused by heritable mitochondrial dysfunction is partially mediated by ANAC017 and improves plant performance.
    Plant J., 2016. 88(4): p. 542-558
    [PMID:27425258]
  4. Hu Z, et al.
    Mitochondrial Defects Confer Tolerance against Cellulose Deficiency.
    Plant Cell, 2016. 28(9): p. 2276-2290
    [PMID:27543091]
  5. Chi YH, et al.
    The membrane-tethered NAC transcription factor, AtNTL7, contributes to ER-stress resistance in Arabidopsis.
    Biochem. Biophys. Res. Commun., 2017. 488(4): p. 641-647
    [PMID:28088515]
  6. Van Aken O,Pogson BJ
    Convergence of mitochondrial and chloroplastic ANAC017/PAP-dependent retrograde signalling pathways and suppression of programmed cell death.
    Cell Death Differ., 2017. 24(6): p. 955-960
    [PMID:28498364]
  7. Cheng P, et al.
    The ERA-Related GTPase AtERG2 Associated with Mitochondria 18S RNA Is Essential for Early Embryo Development in Arabidopsis.
    Front Plant Sci, 2018. 9: p. 182
    [PMID:29497438]