PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa010352

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

WRKY

Protein Properties

Length: 438aa MW: 48826.4 Da PI: 7.286

Description

WRKY family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Lsa#S58684384	PU_ref	Unigene	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	WRKY	95.8	3e-30	265	323	2	59
--SS-EEEEEEE--TT-SS-EEEEEE-ST.T---EEEEEE-SSSTTEEEEEEES--SS- CS WRKY 2 dDgynWrKYGqKevkgsefprsYYrCtsa.gCpvkkkversaedpkvveitYegeHnhe 59 Dg++WrKYGqK kg+++pr+YYrCt+a gC v+k+v+r+a+d +++++tYeg+Hnh+ Lsa010352 265 ADGCQWRKYGQKIAKGNPCPRAYYRCTMAaGCLVRKQVQRCAQDRSILITTYEGNHNHP 323 7*************************99**************************7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:2.20.25.80	9.4E-33	249	325	IPR003657	WRKY domain
SuperFamily	SSF118290	2.62E-27	257	325	IPR003657	WRKY domain
PROSITE profile	PS50811	29.872	259	325	IPR003657	WRKY domain
SMART	SM00774	1.7E-35	264	324	IPR003657	WRKY domain
Pfam	PF03106	1.9E-26	266	323	IPR003657	WRKY domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 438 aa Download sequence Send to blast
MSTPSTGISF DSDRITSDHR HHHQLEFMDS TRHNRSSSSH SPPPTTIHFP VNYLDPDPYK 60 SDDKRINEVD FFNDTKHYPS KSIDFDLNCK EEITKPAIDL DFNVNTRLNL LTGNTSSDQS 120 VIDDGISPSY EDKRANHELV SAQAKLKRMN GENQRLREAL NQVIYNYNAL ENHLAMMIHQ 180 KQRGENPNGE GSRRQVMDLA LTHPAKAETD KNLQLSTSEE RNNDEQSMRP ILNNQNTGNI 240 DQSSEAPIRK ARVSVRARSE ASVIADGCQW RKYGQKIAKG NPCPRAYYRC TMAAGCLVRK 300 QVQRCAQDRS ILITTYEGNH NHPLPPAAMA MASTTSSAAG MLLSGSMPSS DGYLGRNLLP 360 FSSSMATISA SAPFPTITLD LTQTQNPLQF QEPFSNPNHL PHIFGQSLYN HSKFSGLQMS 420 ENMEASSRPG QLLPPAAL

Sequence ? help Back to Top

Protein Sequence Length: 438 aa Download sequence Send to blast

MSTPSTGISF DSDRITSDHR HHHQLEFMDS TRHNRSSSSH SPPPTTIHFP VNYLDPDPYK  60
SDDKRINEVD FFNDTKHYPS KSIDFDLNCK EEITKPAIDL DFNVNTRLNL LTGNTSSDQS  120
VIDDGISPSY EDKRANHELV SAQAKLKRMN GENQRLREAL NQVIYNYNAL ENHLAMMIHQ  180
KQRGENPNGE GSRRQVMDLA LTHPAKAETD KNLQLSTSEE RNNDEQSMRP ILNNQNTGNI  240
DQSSEAPIRK ARVSVRARSE ASVIADGCQW RKYGQKIAKG NPCPRAYYRC TMAAGCLVRK  300
QVQRCAQDRS ILITTYEGNH NHPLPPAAMA MASTTSSAAG MLLSGSMPSS DGYLGRNLLP  360
FSSSMATISA SAPFPTITLD LTQTQNPLQF QEPFSNPNHL PHIFGQSLYN HSKFSGLQMS  420
ENMEASSRPG QLLPPAAL

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1wj2_A	2e-21	255	325	8	77	Probable WRKY transcription factor 4
2lex_A	2e-21	255	325	8	77	Probable WRKY transcription factor 4
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in the control of processes related to senescence and pathogen defense (PubMed:12000796). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:12000796). Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes (PubMed:12000796). Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression (PubMed:25733771). {ECO:0000269\|PubMed:12000796, ECO:0000269\|PubMed:25733771}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By salicylic acid, ethylene, jasmonic acid, pathogens, wounding and strongly during leaf senescence. {ECO:0000269\|PubMed:11449049, ECO:0000269\|PubMed:11722756}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_024979127.1	0.0	WRKY transcription factor 6-like
Swissprot	Q9C519	1e-106	WRKY6_ARATH; WRKY transcription factor 6
TrEMBL	A0A2J6JQS2	0.0	A0A2J6JQS2_LACSA; Uncharacterized protein
STRING	PGSC0003DMT400038852	1e-142	(Solanum tuberosum)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G62300.1	1e-100	WRKY family protein

Publications ? help Back to Top
Zhou F, et al. High humidity suppresses ssi4-mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression. Plant J., 2004. 39(6): p. 920-32 [PMID:15341634] Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P An extracellular subtilase switch for immune priming in Arabidopsis. PLoS Pathog., 2013. 9(6): p. e1003445 [PMID:23818851] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Singh V,Roy S,Singh D,Nandi AK Arabidopsis flowering locus D influences systemic-acquired-resistance- induced expression and histone modifications of WRKY genes. J. Biosci., 2014. 39(1): p. 119-26 [PMID:24499796] Ali MA,Wieczorek K,Kreil DP,Bohlmann H The beet cyst nematode Heterodera schachtii modulates the expression of WRKY transcription factors in syncytia to favour its development in Arabidopsis roots. PLoS ONE, 2014. 9(7): p. e102360 [PMID:25033038] Chai J,Liu J,Zhou J,Xing D Mitogen-activated protein kinase 6 regulates NPR1 gene expression and activation during leaf senescence induced by salicylic acid. J. Exp. Bot., 2014. 65(22): p. 6513-28 [PMID:25210078] Vermeirssen V,De Clercq I,Van Parys T,Van Breusegem F,Van de Peer Y Arabidopsis ensemble reverse-engineered gene regulatory network discloses interconnected transcription factors in oxidative stress. Plant Cell, 2014. 26(12): p. 4656-79 [PMID:25549671] Xiao D, et al. SENESCENCE-SUPPRESSED PROTEIN PHOSPHATASE Directly Interacts with the Cytoplasmic Domain of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE and Negatively Regulates Leaf Senescence in Arabidopsis. Plant Physiol., 2015. 169(2): p. 1275-91 [PMID:26304848] Bakshi M, et al. WRKY6 restricts Piriformospora indica-stimulated and phosphate-induced root development in Arabidopsis. BMC Plant Biol., 2015. 15: p. 305 [PMID:26718529] Huang Y,Feng CZ,Ye Q,Wu WH,Chen YF Arabidopsis WRKY6 Transcription Factor Acts as a Positive Regulator of Abscisic Acid Signaling during Seed Germination and Early Seedling Development. PLoS Genet., 2016. 12(2): p. e1005833 [PMID:26829043] Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P Correction: An Extracellular Subtilase Switch for Immune Priming in Arabidopsis. PLoS Pathog., 2016. 12(11): p. e1006003 [PMID:27806116] Li H, et al. BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis. Mol Plant, 2017. 10(4): p. 545-559 [PMID:28089951] Stetter MG,Benz M,Ludewig U Increased root hair density by loss of WRKY6 in Arabidopsis thaliana. PeerJ, 2017. 5: p. e2891 [PMID:28149680] Zhou X, et al. StMYB44 negatively regulates phosphate transport by suppressing expression of PHOSPHATE1 in potato. J. Exp. Bot., 2017. 68(5): p. 1265-1281 [PMID:28338870] Bakshi M, et al. Piriformospora indica Reprograms Gene Expression in Arabidopsis Phosphate Metabolism Mutants But Does Not Compensate for Phosphate Limitation. Front Microbiol, 2017. 8: p. 1262 [PMID:28747898] Zhang Y, et al. DELLA proteins negatively regulate dark-induced senescence and chlorophyll degradation in Arabidopsis through interaction with the transcription factor WRKY6. Plant Cell Rep., 2018. 37(7): p. 981-992 [PMID:29574486]