PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa012414
Organism
Lactuca sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family bHLH
Protein Properties Length: 482aa    MW: 53732.4 Da    PI: 7.6389
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PUT-187a-Lactuca_sativa-36955PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH40.35.7e-13341387455
                HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
        HLH   4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                +h e+Er+RR+++N++f  Lr ++P+ +      K++Ka+ L  A+ YI +Lq
  Lsa012414 341 NHVEAERQRREKLNQRFYALRAVVPNiS------KMDKASLLGDAISYITDLQ 387
                799***********************66......*****************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142157.0E-4549221IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.085337386IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474598.24E-19340402IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.46E-14340391No hitNo description
Gene3DG3DSA:4.10.280.103.3E-18341400IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.7E-10341387IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.0E-16343392IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 482 aa     Download sequence    Send to blast
MGDKFGLEEE DKAMIENVLG REACDYLLWS ASNKLSDEFR SRTSDLGVQD GLRKILEGSD  60
WNYSIFWQVS NSKSGKSALI WGDGHYKDST ETQAGGGHGT NRKKRVLQKL HSCFKGHEKG  120
NLVAKMDLVS DVEMFYLTSM FYLFPFDKPS SPSQSFNTSR SVWVSDTRSC EEHYQSRSFL  180
AKSARFQTLV FIPLKRGVLE LGSFKSIPED QSFIAMAKTL FNGCHPKGLP KIFGQELSLG  240
GNSNGNGGPK SGPISINFSP KVEEDVDFGG ESYEIPSRNG FGGNSSNNDN EGKLFPNHVM  300
NGVLNSSQSI QSSSPNQDSL MDRKPRKRGR KPANGREEPL NHVEAERQRR EKLNQRFYAL  360
RAVVPNISKM DKASLLGDAI SYITDLQSKI RMMEAEKDVM GAPEVDFMAR KDDAVVRVSC  420
PLDEHPVARV IKTFREHQMV MQDTNVSTTE DGKVMHSFSF QGLAGAAVAQ QLKEKLESVF  480
SD
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A8e-28335397264Transcription factor MYC2
5gnj_B8e-28335397264Transcription factor MYC2
5gnj_E8e-28335397264Transcription factor MYC2
5gnj_F8e-28335397264Transcription factor MYC2
5gnj_G8e-28335397264Transcription factor MYC2
5gnj_I8e-28335397264Transcription factor MYC2
5gnj_M8e-28335397264Transcription factor MYC2
5gnj_N8e-28335397264Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1322330RKPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that negatively regulates jasmonate (JA) signaling (PubMed:30610166). Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection (PubMed:30610166). Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by wounding, feeding with herbivorous insects, infection with the fungal pathogen Botrytis cinerea and infection with the bacterial pathogen Pseudomonas syringae pv tomato DC3000. {ECO:0000269|PubMed:30610166}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023733363.10.0transcription factor bHLH3
RefseqXP_023733364.10.0transcription factor bHLH3
SwissprotA0A3Q7H2160.0MTB3_SOLLC; Transcription factor MTB3
TrEMBLA0A2J6KGD30.0A0A2J6KGD3_LACSA; Uncharacterized protein
STRINGXP_009803066.10.0(Nicotiana sylvestris)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G16430.11e-132bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  3. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]