PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa013836
Organism
Lactuca sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family C2H2
Protein Properties Length: 454aa    MW: 52716.5 Da    PI: 6.8534
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PUT-187a-Lactuca_sativa-55674PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H2120.00064156178323
                ET..TTTEEESSHHHHHHHHHHT CS
    zf-C2H2   3 Cp..dCgksFsrksnLkrHirtH 23 
                C+   Cgk+F +   L++H   H
  Lsa013836 156 CSyeGCGKTFIDAGALRKHSHIH 178
                77779**************7766 PP
2zf-C2H215.93.7e-05183207123
                EEET..TTTEEESSHHHHHHHHHHT CS
    zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                y C+  +Cgk F ++s LkrH   H
  Lsa013836 183 YICHyeNCGKKFLDSSKLKRHYLIH 207
                89*******************9988 PP
3zf-C2H221.46.8e-07213237123
                EEET..TTTEEESSHHHHHHHHHHT CS
    zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                ++Cp   Cgk Fs   nL++H++tH
  Lsa013836 213 FVCPheGCGKAFSLDFNLRSHMKTH 237
                89**********************9 PP
4zf-C2H214.79e-05243267123
                EEET..TTTEEESSHHHHHHHHHHT CS
    zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                + Cp   Cgk++ + + Lk+Hi++H
  Lsa013836 243 HICPysECGKRYAHEYKLKNHIMSH 267
                68**********************6 PP
5zf-C2H212.80.00035311336123
                EEET..TTTEEESSHHHHHHHHHH.T CS
    zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                y Cp   C k + + + L+ H+r+ H
  Lsa013836 311 YACPyeGCEKAYIHEYKLNLHLRReH 336
                89*********************999 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.601.2E-13149180IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.0032154178IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.783154183IPR007087Zinc finger, C2H2
PROSITE patternPS000280156178IPR007087Zinc finger, C2H2
SuperFamilySSF576676.51E-8157207No hitNo description
Gene3DG3DSA:3.30.160.601.2E-13181203IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015714.233183212IPR007087Zinc finger, C2H2
SMARTSM003550.0069183207IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280185207IPR007087Zinc finger, C2H2
SuperFamilySSF576673.93E-14194246No hitNo description
Gene3DG3DSA:3.30.160.609.2E-21204237IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003553.1E-4213237IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.695213242IPR007087Zinc finger, C2H2
PROSITE patternPS000280215237IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.603.0E-8238269IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS501579.91243272IPR007087Zinc finger, C2H2
SMARTSM003550.039243267IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280245268IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.603.3E-8305334IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576673.02E-5305334No hitNo description
PROSITE profilePS501579.556311341IPR007087Zinc finger, C2H2
SMARTSM003550.0097311336IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280313336IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 454 aa     Download sequence    Send to blast
XETVSPFSQC FLAARRSPEF PATVSVFTTS FNRRLISNFP SKFENNLCAR NPNFYVIKPL  60
GSAQLAEQDP IKTTALMDHH SYHNPFERRN FIKSKTPTVK WFKEWVPQDV VSTGGKCFVM  120
KWVTESQLNA MNEEKSKEME AVEPEPEPTT EVLFLCSYEG CGKTFIDAGA LRKHSHIHGE  180
RQYICHYENC GKKFLDSSKL KRHYLIHTGE RNFVCPHEGC GKAFSLDFNL RSHMKTHSQE  240
NYHICPYSEC GKRYAHEYKL KNHIMSHHEK QNNNHMMIEA PLKYVHIQQP IEKPPPKPTK  300
SYTSASSDRP YACPYEGCEK AYIHEYKLNL HLRREHPGHF QEENPKNTDH DHEMDAGSDQ  360
DGHNTGKRVN PKSHKQNRPK PNVRHPPAKV VHHKAPMVGN VMKKQPWPIV KGVYEEEDSE  420
ETEEDRDNGE DRWGYGDRNG EDDDDDDEET EYED
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C2e-361472732123PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023739174.10.0zinc finger transcription factor YY1-like
SwissprotQ2V3L31e-134YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A2J6MBG00.0A0A2J6MBG0_LACSA; Uncharacterized protein
STRINGXP_008365310.11e-160(Malus domestica)
STRINGMigut.B00804.1.p1e-160(Erythranthe guttata)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.11e-128C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]