PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa014343

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

NAC

Protein Properties

Length: 499aa MW: 56381.5 Da PI: 4.3894

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
PUT-187a-Lactuca_sativa-19288	PU_ref	plantGDB	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	175.1	2e-54	14	141	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp..kkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskkge 98 l+pGfrFhPtdeelv +yL++k+ gk++++ ++i++vd+ykvePwdLp +k+k+++ ewyfFs dkky +g+r+nrat++gyWk+tgkd+ v++ +++ Lsa014343 14 LAPGFRFHPTDEELVRYYLRRKICGKPFRF-DAISDVDVYKVEPWDLPdlSKLKSRDLEWYFFSALDKKYGNGSRTNRATEKGYWKTTGKDRVVHH-RSQ 111 579************************9.99**********96448888888********************************99.999 PP NAM 99 lvglkktLvfykgrapkgektdWvmheyrl 128 +vg+kktLv+++grapkge+t+Wvmheyrl Lsa014343 112 QVGMKKTLVYHSGRAPKGERTNWVMHEYRL 141 **************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	2.75E-63	11	164	IPR003441	NAC domain
PROSITE profile	PS51005	58.522	14	164	IPR003441	NAC domain
Pfam	PF02365	3.6E-28	16	141	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 499 aa Download sequence Send to blast
MALSIDSTPV ASSLAPGFRF HPTDEELVRY YLRRKICGKP FRFDAISDVD VYKVEPWDLP 60 DLSKLKSRDL EWYFFSALDK KYGNGSRTNR ATEKGYWKTT GKDRVVHHRS QQVGMKKTLV 120 YHSGRAPKGE RTNWVMHEYR LIDQELEKAG IIQDAFVLCR IFRKSGSGPK NGEKYGAPFI 180 EEEWEDEDES VVVPKQEDCT QELPVDEDSY LDANDIEQIL NTDMPVEDVP LPLNFNQDDY 240 SNIISNSDES NKSFDPPVQT VFHEHVEEQS NPMNFDIDYL LDQPYFDATS DFPLDETLFF 300 EANDLKDDVN TDSGLDILDE YMSFYNSDLD NFQPTFDSLQ NDNIALDSSS VLKGTHQEQN 360 NDKDIASSSK KEHADQETDI AYPFLKKASY MLENISAPPA FASEFPAKYM ASGSHGQSSV 420 NVTSGMIHIS NVSFGSGAMD FSLGKNTQLN IVVSFGDMNT GKVNSGGSRS WFYCGLLWIL 480 VASLSFKIGS LVCSRSFMS

Sequence ? help Back to Top

Protein Sequence Length: 499 aa Download sequence Send to blast

MALSIDSTPV ASSLAPGFRF HPTDEELVRY YLRRKICGKP FRFDAISDVD VYKVEPWDLP  60
DLSKLKSRDL EWYFFSALDK KYGNGSRTNR ATEKGYWKTT GKDRVVHHRS QQVGMKKTLV  120
YHSGRAPKGE RTNWVMHEYR LIDQELEKAG IIQDAFVLCR IFRKSGSGPK NGEKYGAPFI  180
EEEWEDEDES VVVPKQEDCT QELPVDEDSY LDANDIEQIL NTDMPVEDVP LPLNFNQDDY  240
SNIISNSDES NKSFDPPVQT VFHEHVEEQS NPMNFDIDYL LDQPYFDATS DFPLDETLFF  300
EANDLKDDVN TDSGLDILDE YMSFYNSDLD NFQPTFDSLQ NDNIALDSSS VLKGTHQEQN  360
NDKDIASSSK KEHADQETDI AYPFLKKASY MLENISAPPA FASEFPAKYM ASGSHGQSSV  420
NVTSGMIHIS NVSFGSGAMD FSLGKNTQLN IVVSFGDMNT GKVNSGGSRS WFYCGLLWIL  480
VASLSFKIGS LVCSRSFMS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ut4_A	2e-50	13	170	16	171	NO APICAL MERISTEM PROTEIN
1ut4_B	2e-50	13	170	16	171	NO APICAL MERISTEM PROTEIN
1ut7_A	2e-50	13	170	16	171	NO APICAL MERISTEM PROTEIN
1ut7_B	2e-50	13	170	16	171	NO APICAL MERISTEM PROTEIN
3swm_A	1e-50	13	170	19	174	NAC domain-containing protein 19
3swm_B	1e-50	13	170	19	174	NAC domain-containing protein 19
3swm_C	1e-50	13	170	19	174	NAC domain-containing protein 19
3swm_D	1e-50	13	170	19	174	NAC domain-containing protein 19
3swp_A	1e-50	13	170	19	174	NAC domain-containing protein 19
3swp_B	1e-50	13	170	19	174	NAC domain-containing protein 19
3swp_C	1e-50	13	170	19	174	NAC domain-containing protein 19
3swp_D	1e-50	13	170	19	174	NAC domain-containing protein 19
4dul_A	2e-50	13	170	16	171	NAC domain-containing protein 19
4dul_B	2e-50	13	170	16	171	NAC domain-containing protein 19
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (Ref.6, PubMed:24323506, PubMed:25219309). Promotes reactive oxygen species (ROS) production during drought-induced leaf senescence. In response to abscisic acid (ABA)-mediated drought stress signals, binds directly to the promoters of RBOHC and RBOHE genes, encoding ROS biosynthetic enzymes, resulting in ROS accumulation and triggering leaf senescence via programmed cell death (PCD). ROS-induced leaf senescence sustains plant survival under drought conditions (PubMed:22313226). Involved in heat stress response. Modulates PCD through a ROS-mediated positive feedback control under heat stress conditions. This may provide an adaptation strategy for plant survival under extreme heat stress conditions (PubMed:25219309). Acts as repressor in preventing anther dehiscence during stamen development by suppressing genes that participate in jasmonic acid (JA) biosynthesis, such as DAD1, AOS, AOC3, OPR3 and 4CLL5/OPCL1 (PubMed:24323506). {ECO:0000269\|PubMed:22313226, ECO:0000269\|PubMed:24323506, ECO:0000269\|PubMed:25219309, ECO:0000269\|Ref.6}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By abscisic acid (ABA) (PubMed:22313226, PubMed:25219309). Induced by heat shock (PubMed:25219309). Induced by cold, drought stress and methyl methanesulfonate (MMS) treatment (PubMed:17158162). {ECO:0000269\|PubMed:17158162, ECO:0000269\|PubMed:22313226, ECO:0000269\|PubMed:25219309}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023762703.1	0.0	NAC domain-containing protein 53
Swissprot	Q949N0	1e-139	NAC53_ARATH; NAC domain-containing protein 53
TrEMBL	A0A2J6LGA0	0.0	A0A2J6LGA0_LACSA; Uncharacterized protein
STRING	XP_002532627.1	1e-168	(Ricinus communis)
STRING	PGSC0003DMT400060090	1e-168	(Solanum tuberosum)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G10500.1	1e-133	NAC domain containing protein 53

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Vermeirssen V,De Clercq I,Van Parys T,Van Breusegem F,Van de Peer Y Arabidopsis ensemble reverse-engineered gene regulatory network discloses interconnected transcription factors in oxidative stress. Plant Cell, 2014. 26(12): p. 4656-79 [PMID:25549671] Gladman NP,Marshall RS,Lee KH,Vierstra RD The Proteasome Stress Regulon Is Controlled by a Pair of NAC Transcription Factors in Arabidopsis. Plant Cell, 2016. 28(6): p. 1279-96 [PMID:27194708] Sanz-Fernández M, et al. Screening Arabidopsis mutants in genes useful for phytoremediation. J. Hazard. Mater., 2017. 335: p. 143-151 [PMID:28441590]