PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa014695
Organism
Lactuca sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family bHLH
Protein Properties Length: 685aa    MW: 75409.1 Da    PI: 5.6553
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Lsa#S58694144PU_refUnigeneView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH37.25.3e-12501546454
                HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
        HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  Lsa014695 501 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAILYINEL 546
                799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142158.8E-5474254IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.844497546IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.22E-17500570IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.86E-14500550No hitNo description
Gene3DG3DSA:4.10.280.104.0E-17501568IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.0E-9501546IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-15503552IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 685 aa     Download sequence    Send to blast
MTDYRLQTMN HWTPDDNVSM MDAFISSDMT SIWANHGTSQ SHTHAPPVTV PPASSSASTS  60
APHKIVNEFN PDTLQQRLQG MIDTARESWT YAIFWQSSDV EFADTPVLGW GDGYYKGEVN  120
KVKTAPSATS MAEQQYRKKV LRELNSLISG SQAPESDAVD EEVTDTEWFF LISMTQSFAN  180
GNGLPGQAAF TNQPVWVAGR ERLMASHCER VRQGQGFGLQ TIVCIPCTDG VIELGSTELI  240
FQSSDVMKKV KVSFNFSNSP DIMQINTDQV AVAGGDHDPS SIWLTDPVAT STVTTDVTTI  300
KDSVDVIGSQ ATTVIPSITS HVPKHLPFEN PSSSSILENP RYIHNPNPDS LQNQGVFGSR  360
ELNFSEFRSF DGATGGRNGN GRILDFGESK RSSTNNNNNG GLFSGQSQFI GAEENNKNKK  420
KRSPGSCGSN EDGMLSFVSG VLPSSSTVKS GGCTFPGADS DHSDLDASVI REVESSRMVE  480
PEKKPRKRGR KPANGREEPL NHVEAERQRR EKLNQRFYAL RAVVPNVSKM DKASLLGDAI  540
LYINELKSKL DNTICDKEEL RNQIDELKKE LLSKESRQSS SSAISHPEDM KMSNTSTTNQ  600
PILDLDVEVK VIGWDAMIRV QCNKKNHPAA RLMAALKELD FEVNHASVSV VNELMIQQAT  660
VKMGGRLYTQ DQLRLALTNR FSDPL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A5e-65682563194Transcription factor MYC3
4rqw_B5e-65682563194Transcription factor MYC3
4rs9_A5e-65682563194Transcription factor MYC3
4yz6_A5e-65682563194Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1482490KKPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023736226.10.0transcription factor MYC2-like
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A2J6KA970.0A0A2J6KA97_LACSA; Uncharacterized protein
STRINGVIT_02s0012g01320.t010.0(Vitis vinifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.10.0bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]