PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lsa018599

Organism

Lactuca sativa

Taxonomic ID

4236

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

E2F/DP

Protein Properties

Length: 411aa MW: 45308.6 Da PI: 4.4034

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Lsa#S58693579	PU_ref	Unigene	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.3	2.2e-27	100	165	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Lsa018599 100 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 165 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.6E-29	98	167	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.11E-17	100	163	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.3E-34	100	165	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.6E-24	102	165	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	3.36E-47	175	281	No hit	No description
SuperFamily	SSF144074	3.4E-32	177	281	No hit	No description
Pfam	PF16421	9.4E-33	180	279	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 411 aa Download sequence Send to blast
MKPPPFGDYH RFSSTTAAHH ESEGIVVKTP PLKRKGDATN EQSQSPTPGN TLATTTSLQT 60 PVSGKASKPQ KIPRIGKCNR AGSNADSPSG NNLTPVGPCR YDSSLGLLTK KFINLIKHAE 120 DGILDLNKAA ETLEVQKRRI YDITNVLEGI GLIEKKLKNR IQWKGLDASK GEVDESIASL 180 QEEVENLSVE ELRLDEETRE MQERLRDLSE DENNQKWLFV TEDDIKSLPC FQEETLIAIK 240 APHGTTLEVP DPDEGVDHLQ RRYRIVLRST MGPIDVYLVS QFEEKVEEMN GGIPPSSLGM 300 VENPTKETTM DERQGTDAGA HTSEDFVSAG IMKIVPDIDS DADYWLLSEA DVSITDIWTT 360 ESSVEWNDLD MLHNDYTMPM PLPGVTVTTP PTSDANPPTP TPTPTGTDCL G

Sequence ? help Back to Top

Protein Sequence Length: 411 aa Download sequence Send to blast

MKPPPFGDYH RFSSTTAAHH ESEGIVVKTP PLKRKGDATN EQSQSPTPGN TLATTTSLQT  60
PVSGKASKPQ KIPRIGKCNR AGSNADSPSG NNLTPVGPCR YDSSLGLLTK KFINLIKHAE  120
DGILDLNKAA ETLEVQKRRI YDITNVLEGI GLIEKKLKNR IQWKGLDASK GEVDESIASL  180
QEEVENLSVE ELRLDEETRE MQERLRDLSE DENNQKWLFV TEDDIKSLPC FQEETLIAIK  240
APHGTTLEVP DPDEGVDHLQ RRYRIVLRST MGPIDVYLVS QFEEKVEEMN GGIPPSSLGM  300
VENPTKETTM DERQGTDAGA HTSEDFVSAG IMKIVPDIDS DADYWLLSEA DVSITDIWTT  360
ESSVEWNDLD MLHNDYTMPM PLPGVTVTTP PTSDANPPTP TPTPTGTDCL G

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	8e-26	95	166	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023762504.1	0.0	transcription factor E2FB-like
Swissprot	Q9FV71	1e-137	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A2J6LGM7	0.0	A0A2J6LGM7_LACSA; Uncharacterized protein
STRING	VIT_06s0080g01110.t01	0.0	(Vitis vinifera)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-138	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]