PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MDP0000124555

Organism

Malus domestica

Taxonomic ID

3750

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus

Family

MYB

Protein Properties

Length: 223aa MW: 25437.5 Da PI: 10.1823

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MDP0000124555	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	66.5	4.6e-21	29	76	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 rg+WT+eEd++l+++++ +G ++WktIa++ g++R++k+c++rw++yl MDP0000124555 29 RGAWTAEEDQKLAEVIEIHGAKRWKTIASKAGLNRCGKSCRLRWLNYL 76 89********************************************97 PP
2	Myb_DNA-binding	52.9	8.5e-17	82	127	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 rg+ +++E++l+v+++k+lG++ W++Ia +++ gRt++++k++w+++l MDP0000124555 82 RGNISEQEEDLIVRLHKLLGNR-WSLIAGRLP-GRTDNEIKNYWNSHL 127 7899****************.*****.**********986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	26.524	24	80	IPR017930	Myb domain
SuperFamily	SSF46689	4.12E-30	27	123	IPR009057	Homeodomain-like
SMART	SM00717	3.0E-17	28	78	IPR001005	SANT/Myb domain
Pfam	PF00249	2.6E-19	29	76	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	1.8E-25	30	83	IPR009057	Homeodomain-like
CDD	cd00167	5.87E-12	31	76	No hit	No description
SMART	SM00717	8.1E-16	81	129	IPR001005	SANT/Myb domain
PROSITE profile	PS51294	20.438	81	131	IPR017930	Myb domain
Pfam	PF00249	5.0E-15	82	127	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	5.6E-25	84	132	IPR009057	Homeodomain-like
CDD	cd00167	3.81E-10	86	127	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 223 aa Download sequence Send to blast
MDPVTKGSIN RRKVKGVEAM KNTKREVNRG AWTAEEDQKL AEVIEIHGAK RWKTIASKAG 60 LNRCGKSCRL RWLNYLRPNI KRGNISEQEE DLIVRLHKLL GNRWSLIAGR LPGRTDNEIK 120 NYWNSHLSKR MNQKEKQNGA NLTRQMISTD HQKDRVQMKE DSSSEEGATS TSTSTTSAAS 180 KGGDQNSNIN IDVDDFFDFS NEGLLNLEWV SKFLGQDDGR WFN

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1h8a_C	8e-30	26	131	24	128	MYB TRANSFORMING PROTEIN
Search in ModeBase

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Restricted to roots and hypocotyl. Specifically expressed in root non-hair developing cells (atrichoblasts) at the N position. Also present in lateral root cap cells. In hypocotyls, expressed within files of epidermal cells located outside a single cortical cell equivalent to roots N cells (at protein level). {ECO:0000269\|PubMed:10589676, ECO:0000269\|PubMed:14627722, ECO:0000269\|PubMed:16207757}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in roots and hypocotyl. Together with GL3 or BHLH2, promotes the formation of non-hair developing cells (atrichoblasts) et the N position in root epidermis. Regulates stomata spatial distribution in hypocotyls. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes such as GL2 and of CPC. {ECO:0000269\|PubMed:10589676, ECO:0000269\|PubMed:11585796, ECO:0000269\|PubMed:14627722, ECO:0000269\|PubMed:15361138, ECO:0000269\|PubMed:15795220, ECO:0000269\|PubMed:16207757}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Transcriptional activation correlates with reduced histone acetylation on H3 and H4 mediated by HDA18 in N cells. Repressed by CPC in hair cells (H position). {ECO:0000269\|PubMed:11910008, ECO:0000269\|PubMed:16176989}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008391385.1	1e-164	transcription factor WER-like
Swissprot	Q9SEI0	1e-53	WER_ARATH; Transcription factor WER
TrEMBL	A0A498IZX9	1e-149	A0A498IZX9_MALDO; Uncharacterized protein
STRING	XP_008391385.1	1e-164	(Malus domestica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2148	32	88

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G14750.1	6e-55	myb domain protein 66

Link Out ? help Back to Top
Phytozome	MDP0000124555

Publications ? help Back to Top
Savage N, et al. Positional signaling and expression of ENHANCER OF TRY AND CPC1 are tuned to increase root hair density in response to phosphate deficiency in Arabidopsis thaliana. PLoS ONE, 2013. 8(10): p. e75452 [PMID:24130712] Cheng Y, et al. Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases. Elife, 2018. [PMID:24771765] Kiefer CS, et al. Correction: Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity. Development, 2015. 142(5): p. 1022 [PMID:25715402] Kwak SH,Song SK,Lee MM,Schiefelbein J TORNADO1 regulates root epidermal patterning through the WEREWOLF pathway in Arabidopsis thaliana. Plant Signal Behav, 2015. 10(12): p. e1103407 [PMID:26451798] Zhu Y, et al. The Histone Chaperone NRP1 Interacts with WEREWOLF to Activate GLABRA2 in Arabidopsis Root Hair Development. Plant Cell, 2017. 29(2): p. 260-276 [PMID:28138017] Canales J,Contreras-López O,Álvarez JM,Gutiérrez RA Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana. Plant J., 2017. 92(2): p. 305-316 [PMID:28771873] Mira MM, et al. Expression of Arabidopsis class 1 phytoglobin (AtPgb1) delays death and degradation of the root apical meristem during severe PEG-induced water deficit. J. Exp. Bot., 2017. 68(20): p. 5653-5668 [PMID:29059380] Kohanová J, et al. Root hair abundance impacts cadmium accumulation in Arabidopsis thaliana shoots. Ann. Bot., 2018. 122(5): p. 903-914 [PMID:29394308]