PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000124881
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family E2F/DP
Protein Properties Length: 305aa    MW: 34741.8 Da    PI: 8.1165
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000124881genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP60.91.9e-1981133158
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnl 58 
                    r ++sL+llt+kf+kl+ ++++++++ln  a+ L   +v  ++RRiYDi+NVLe++nl
  MDP0000124881  81 RFDNSLGLLTKKFIKLIYEAKDRTLDLNRTAEVL---EV--QKRRIYDITNVLEGINL 133
                    6799******************************...99..***************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.6E-1880133IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.13E-1181133IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.9E-1781148IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-1683133IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440748.11E-21134228No hitNo description
CDDcd146602.23E-30134228No hitNo description
PfamPF164214.4E-24135228IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 305 aa     Download sequence    Send to blast
MSLLVKLRPK QEIDNDTQIG GQEAAAGPSK VMKGILPLPQ SCSGAKHNGK LKVPKHTKVX  60
TQRSTADFCN GLGPAQAIGC RFDNSLGLLT KKFIKLIYEA KDRTLDLNRT AEVLEVQKRR  120
IYDITNVLEG INLDEVESLX EEECRLDDAI XEKQELLRAL EQDEKYLFXT EEDISSLHCF  180
QNQTLIAIKA PQASYIEVVD PDEDISFQQR QFRMIVKSTI GPIDVYLLRP MMIIGLDQNL  240
MLALQIYGRI RXGPKAKTSF KTVLRRVAQR WAMNIDRSVN GIRXLIVPDD MREYHILFLF  300
CHTKV
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-1480138665PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.23441e-124leaf
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected at the G1/S transition, but increases during the progression into S phase and peaks after the passage into G2. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:12468727}.
UniprotTISSUE SPECIFICITY: Expressed in meristematic areas, vascular tissues, apical part of the roots, cotyledons, upper region of the hypocotyls, trichomes, young flower buds and pollen grains. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782}.
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008357153.21e-147transcription factor E2FC
SwissprotQ9FV703e-59E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A498JBD51e-140A0A498JBD5_MALDO; Uncharacterized protein
STRINGXP_008377229.11e-151(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF118852529
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.21e-61E2F/DP family protein
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]