PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000150467
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family E2F/DP
Protein Properties Length: 461aa    MW: 51167.8 Da    PI: 4.9073
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000150467genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.73e-2679151171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    r ++sL+llt+kf++l++++e+gi++ln++a++L  e     +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  MDP0000150467  79 RFDSSLGLLTKKFINLIKHAEDGILDLNKAADTL--EvttflSV-VQKRRIYDITNVLEGIGLIEKKLKNRIQWKG 151
                    6789******************************..66799955.5****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.4E-2777153IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.2E-3279151IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.76E-1579149IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.9E-2381151IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF164217.9E-23160249IPR032198E2F transcription factor, CC-MB domain
SuperFamilySSF1440741.33E-24163251No hitNo description
CDDcd146601.13E-36166251No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 461 aa     Download sequence    Send to blast
MLKRKSDAVD CEAESSDRTT APGYTDVGNS PLQTPMSTKV GKANKTSRLT KCSKSGPXTP  60
ASNVGSPSGA NVTPAGPCRF DSSLGLLTKK FINLIKHAED GILDLNKAAD TLEVTTFLSV  120
VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GLDVSRTGDV DENYPSLQAQ VENLSIEEXR  180
LDQQIRWLFV TEEDIKGLPC LQNETLIAIK APHGTTLEVP DPDEAVDYPQ RRYRMVLRST  240
MGPIDVYLVS QFEEKFEEIN GVEVPTNIAA TSGANENPAT TMVSEDRGKD VELQVPDDHT  300
MSADPTAAQD LTGGIMKIVP SDVDSDADYW LLSDADISIT DLWRXEHAGM FWEPVMSNHL  360
PYLFDLGGWV EGSGSCPSVP GKTHRRHKEQ RNESNQQAFV GVTGVKAGYR RIENVSMVVR  420
PHNHLVMFSI TLYAELELLX FRIPNYFMTV RFEGYSPLLS L
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-2574152274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant at the G1/S transition. Lower but constant level in the following phases. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:16514015}.
UniprotTISSUE SPECIFICITY: Expressed in proliferating cells and several differentiated tissues. Detected in inflorescence and shoot apical meristems, cotyledonary vascular tissues, leaf primordia, young leaves, base of trichomes, central cylinder and elongation zone of roots, lateral root primordia, flowers, pistils of immature flowers and pollen grains. {ECO:0000269|PubMed:16514015}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028955764.10.0transcription factor E2FB-like isoform X1
SwissprotQ9FV711e-121E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A498KBY80.0A0A498KBY8_MALDO; Uncharacterized protein
STRINGXP_008361438.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.31e-124E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]