PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000248838
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family E2F/DP
Protein Properties Length: 260aa    MW: 28580.3 Da    PI: 8.466
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000248838genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP66.63.3e-2131110171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse...........dvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    rk+ksL+ll+++fl l+++   + + l+++a++L               v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  MDP0000248838  31 RKQKSLGLLCSNFLGLYNRDGVTSIGLDDAASRLGLHlspisxsfalsCV--ERRRIYDIVNVLESVGVLARKAKNQYSWKG 110
                    79*****************999************555999******9666..9***************************98 PP
2E2F_TDP69.44.3e-22195260161
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek 61 
                    r+eksL lltq+f+kl+ +s+ ++++l+e+ak L+ +      +++k+RRiYDi+NVL+++nliek
  MDP0000248838 195 RREKSLALLTQNFVKLFVCSTVEMISLDEAAKLLLGDahnasVMRTKVRRIYDIANVLSSMNLIEK 260
                    689**************************************999*********************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.5E-2327112IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.98E-1330108IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.5E-2231110IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.9E-1832110IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.7E-19191260IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.9E-19195260IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.18E-10197260IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023199.3E-17197260IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 260 aa     Download sequence    Send to blast
MADPPPPPPA PAQSSAPAPT GPSARNHGYS RKQKSLGLLC SNFLGLYNRD GVTSIGLDDA  60
ASRLGLHLSP ISXSFALSCV ERRRIYDIVN VLESVGVLAR KAKNQYSWKG FKAIPNALQE  120
LREEGLRENI CNFDGNEDPK ASLLGVFFIG LSIRSNKGLQ ISDDEDDVER CGSQQTENSN  180
PYLNIKPMNP KSDNRREKSL ALLTQNFVKL FVCSTVEMIS LDEAAKLLLG DAHNASVMRT  240
KVRRIYDIAN VLSSMNLIEK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-33302603221Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008374485.21e-145E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ48e-82E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A498I5U61e-131A0A498I5U6_MALDO; Uncharacterized protein
STRINGXP_008346821.11e-146(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.12e-84DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]