PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000258167
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family NAC
Protein Properties Length: 723aa    MW: 78308.7 Da    PI: 5.961
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000258167genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM167.35.2e-52351621128
            NAM   1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp.k.kvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevls 94 
                    l+pGfrFhPtdeelv +yLk+kv +k++++ ++i+evdiyk+ePwdL  k ++k++++e+yfFs  d+ky +g r nrat++gyWkatg+d++v++
  MDP0000258167  35 LAPGFRFHPTDEELVIYYLKRKVCRKPFKF-NAISEVDIYKSEPWDLAdKsSLKSRDQEYYFFSALDRKYGNGARMNRATNQGYWKATGNDRPVKH 129
                    579**************************9.89**************75347888999************************************** PP

            NAM  95 kkgelvglkktLvfykgrapkgektdWvmheyrl 128
                     ++ +vg+kktLvf++grap+g++t+Wvmheyrl
  MDP0000258167 130 -NDIVVGMKKTLVFHSGRAPDGKRTNWVMHEYRL 162
                    .999****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019413.79E-5933187IPR003441NAC domain
PROSITE profilePS5100556.235187IPR003441NAC domain
PfamPF023653.2E-2637162IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 723 aa     Download sequence    Send to blast
MGREADLQII ASAAADVAVA APLVPPTLPP APTALAPGFR FHPTDEELVI YYLKRKVCRK  60
PFKFNAISEV DIYKSEPWDL ADKSSLKSRD QEYYFFSALD RKYGNGARMN RATNQGYWKA  120
TGNDRPVKHN DIVVGMKKTL VFHSGRAPDG KRTNWVMHEY RLVDEVFEKA GLGAIQDAFV  180
LCRVFHKSNI GPPNGHRYAP FVEEEWDDDD KLTLVPGQET RTVAVVSRDA FVVGNGHAAC  240
XEQNDYAAGN EQKVHAAGSE QKVHAARSEQ NGLSAYIRGN GHAAYTGGNG HAAHIGGNGH  300
AVXIGGNGXA AYNGENGXGT SVEGNGHGTS MEGIAHGTSV EXTGHGTSVK GSGHSTSVEG  360
RGXXTSVERN GHGTSVEGSG HRTSVEENGH GISVEGNVVE GIGHGAIIVV DDNGTTNEGD  420
CHETCTAGNG HSVPSXENNI EQGDKKTIIV TWIELFERPG GEGEVLKRPN EICRAIXVVQ  480
NTQAISKAIV VVPELPAENX TVLPPCKTEK TDDYPMTCVV NREERLDDYP SPGPDDAQPL  540
LTLFNRQPGQ LRQYKRRRHN DSNSNHSNAS EISSGMTHDP CSSTTTTAST EASMTTTRNF  600
LSALVEYQLL ESLEPKDTTP APPPELNAAL MESSVPTSCL KYIETLQTEI HKISIERETL  660
KFEMMSAQAM INILQARIDL LNKENEDLKK KYKVVLRSDG SNNGGGGGGG DMMVKMVITM  720
VEW
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3swm_A2e-45241899170NAC domain-containing protein 19
3swm_B2e-45241899170NAC domain-containing protein 19
3swm_C2e-45241899170NAC domain-containing protein 19
3swm_D2e-45241899170NAC domain-containing protein 19
3swp_A2e-45241899170NAC domain-containing protein 19
3swp_B2e-45241899170NAC domain-containing protein 19
3swp_C2e-45241899170NAC domain-containing protein 19
3swp_D2e-45241899170NAC domain-containing protein 19
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.65320.0bud| fruit| stem
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Mostly expressed in floral organs, and, at low levels, in other organs. {ECO:0000269|PubMed:25578968}.
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional repressor that binds to the motif 5'-(C/T)A(C/A)G-3' in the promoter of target genes (PubMed:25578968). Binds also to the 5'-CTTGNNNNNCAAG-3' consensus sequence in chromatin (PubMed:26617990). Can bind to the mitochondrial dysfunction motif (MDM) present in the upstream regions of mitochondrial dysfunction stimulon (MDS) genes involved in mitochondrial retrograde regulation (MRR) (PubMed:24045019). Together with NAC050 and JMJ14, regulates gene expression and flowering time by associating with the histone demethylase JMJ14, probably by the promotion of RNA-mediated gene silencing (PubMed:25578968, PubMed:26617990). Regulates siRNA-dependent post-transcriptional gene silencing (PTGS) through SGS3 expression modulation (PubMed:28207953). Required during pollen development (PubMed:19237690). {ECO:0000269|PubMed:19237690, ECO:0000269|PubMed:24045019, ECO:0000269|PubMed:25578968, ECO:0000269|PubMed:26617990, ECO:0000269|PubMed:28207953}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by type III effector proteins (TTEs) secreted by the pathogenic bacteria P.syringae pv. tomato DC3000 during basal defense. {ECO:0000269|PubMed:16553893}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008375621.20.0NAC domain containing protein 50-like
SwissprotQ9SQY01e-93NAC52_ARATH; NAC domain containing protein 52
TrEMBLA0A498JCB00.0A0A498JCB0_MALDO; Uncharacterized protein
STRINGXP_008375621.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF81893241
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G10490.13e-93NAC domain containing protein 52
Publications ? help Back to Top
  1. Higgins JD,Ferdous M,Osman K,Franklin FC
    The RecQ helicase AtRECQ4A is required to remove inter-chromosomal telomeric connections that arise during meiotic recombination in Arabidopsis.
    Plant J., 2011. 65(3): p. 492-502
    [PMID:21265901]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Zhang S, et al.
    C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association.
    Cell Discov, 2019.
    [PMID:26617990]
  4. Butel N,Le Masson I,Bouteiller N,Vaucheret H,Elmayan T
    sgs1: a neomorphic nac52 allele impairing post-transcriptional gene silencing through SGS3 downregulation.
    Plant J., 2017. 90(3): p. 505-519
    [PMID:28207953]
  5. Elmayan T, et al.
    Arabidopsis mutants impaired in cosuppression.
    Plant Cell, 1998. 10(10): p. 1747-58
    [PMID:9761800]