PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000265073
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family NAC
Protein Properties Length: 541aa    MW: 59818.4 Da    PI: 7.8309
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000265073genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM98.97.5e-3133744328128
            NAM  28 leleevikevdiykvePwdLp.k.....kvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskkgelvglkktLvfykgrapkge 117
                     +++ + ++v  y++ P++   +     k+++  ++wyfF++rd+ky++g+r++ra+ +gyWkatg dkev+s++g++vg +k Lvfy+g+ pkg 
  MDP0000265073 337 ASVTIITQQVASYSLSPNKQSpAqggqeKYEKYGDKWYFFTPRDRKYRNGSRPKRAAGDGYWKATGADKEVKSSDGAVVGSRKALVFYRGKPPKGD 432
                    333335677899999999985334665555555669************************************************************ PP

            NAM 118 ktdWvmheyrl 128
                    kt+W+mhe+++
  MDP0000265073 433 KTNWIMHEFKV 443
                    *********87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF517355.94E-643318IPR016040NAD(P)-binding domain
Gene3DG3DSA:3.40.50.7202.4E-588315IPR016040NAD(P)-binding domain
CDDcd089585.31E-1529301No hitNo description
PfamPF013703.1E-209246IPR001509NAD-dependent epimerase/dehydratase, N-terminal domain
PROSITE profilePS5100531.606297465IPR003441NAC domain
PfamPF023652.5E-14333442IPR003441NAC domain
SuperFamilySSF1019412.22E-29369448IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003824Molecular Functioncatalytic activity
GO:0050662Molecular Functioncoenzyme binding
Sequence ? help Back to Top
Protein Sequence    Length: 541 aa     Download sequence    Send to blast
MSSGEGKVVC VTGASGYIAS WLVKLLLQRG YTVKASIRDP NDPTKTEHLH ALDGAQDRLQ  60
LFKANLLEXG SFDSAVEGCE GVFHTASPFY HDVTDPKAEL LEPAVKGTLN VLNSCAKSPS  120
IKRVVLTSSI AAVAYNGKPR TPDVVIDETW FTDPDVCKES KLWYVLSKTL AEDAAWKFVK  180
EKGIDLVTIN PAMVIGPLLQ PTLNTSAAAV LNVIKGARTF PNASFGWINV KDVANAHIQA  240
FESPTASGRY CLVETVAHFS EVVRILRELH PTLQLPEKCA DDKPFVPTYQ VSKEKAKXLG  300
VEFIPLDVSL KETVESLKEK ESPTMEPVEQ SHPDHKASVT IITQQVASYS LSPNKQSPAQ  360
GGQEKYEKYG DKWYFFTPRD RKYRNGSRPK RAAGDGYWKA TGADKEVKSS DGAVVGSRKA  420
LVFYRGKPPK GDKTNWIMHE FKVKDSPVRS RRGENDMRSV EAASMNAGSY YANMGYSQPI  480
CVRPPSMSSE SVLGPYRYID ESTILQDDMM FGMKGFEHSL YSTNNYAGQF SALDHVFPYT  540
E
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4qtz_A0.063212317Dihydroflavonol-4-reductase
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.26250.0bud| cell culture| fruit| leaf| root| stem
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in leaves, stems and flowers.
Functional Description ? help Back to Top
Source Description
UniProtInvolved in the latter stages of lignin biosynthesis. Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes. {ECO:0000269|PubMed:11389761, ECO:0000269|PubMed:11430991, ECO:0000269|PubMed:16122934, ECO:0000269|PubMed:16153410, ECO:0000269|PubMed:18046574, ECO:0000269|PubMed:19674336, ECO:0000269|PubMed:20829305}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankJX2903760.0JX290376.1 Pyrus pyrifolia cinnamyl alcohol dehydrogenase 1 (CAD1) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008363357.20.0cinnamoyl-CoA reductase 1
SwissprotQ9S9N92e-91CCR1_ARATH; Cinnamoyl-CoA reductase 1
TrEMBLA0A498KCL40.0A0A498KCL4_MALDO; Uncharacterized protein
STRINGXP_008363567.10.0(Malus domestica)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G77450.14e-31NAC domain containing protein 32
Publications ? help Back to Top
  1. Jones L,Ennos AR,Turner SR
    Cloning and characterization of irregular xylem4 (irx4): a severely lignin-deficient mutant of Arabidopsis.
    Plant J., 2001. 26(2): p. 205-16
    [PMID:11389761]
  2. Lauvergeat V, et al.
    Two cinnamoyl-CoA reductase (CCR) genes from Arabidopsis thaliana are differentially expressed during development and in response to infection with pathogenic bacteria.
    Phytochemistry, 2001. 57(7): p. 1187-95
    [PMID:11430991]
  3. Baltas M, et al.
    Kinetic and inhibition studies of cinnamoyl-CoA reductase 1 from Arabidopsis thaliana.
    Plant Physiol. Biochem., 2005. 43(8): p. 746-53
    [PMID:16122934]
  4. Patten AM, et al.
    Reassessment of effects on lignification and vascular development in the irx4 Arabidopsis mutant.
    Phytochemistry, 2005. 66(17): p. 2092-107
    [PMID:16153410]
  5. Laskar DD, et al.
    The Arabidopsis cinnamoyl CoA reductase irx4 mutant has a delayed but coherent (normal) program of lignification.
    Plant J., 2006. 48(5): p. 674-86
    [PMID:17092316]
  6. Mir Derikvand M, et al.
    Redirection of the phenylpropanoid pathway to feruloyl malate in Arabidopsis mutants deficient for cinnamoyl-CoA reductase 1.
    Planta, 2008. 227(5): p. 943-56
    [PMID:18046574]
  7. Bischoff V,Cookson SJ,Wu S,Scheible WR
    Thaxtomin A affects CESA-complex density, expression of cell wall genes, cell wall composition, and causes ectopic lignification in Arabidopsis thaliana seedlings.
    J. Exp. Bot., 2009. 60(3): p. 955-65
    [PMID:19269997]
  8. Ruel K, et al.
    Impact of CCR1 silencing on the assembly of lignified secondary walls in Arabidopsis thaliana.
    New Phytol., 2009. 184(1): p. 99-113
    [PMID:19674336]
  9. Thévenin J, et al.
    The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
    Mol Plant, 2011. 4(1): p. 70-82
    [PMID:20829305]
  10. Liu L, et al.
    A knockout mutation in the lignin biosynthesis gene CCR1 explains a major QTL for acid detergent lignin content in Brassica napus seeds.
    Theor. Appl. Genet., 2012. 124(8): p. 1573-86
    [PMID:22350089]
  11. Vanholme R, et al.
    A systems biology view of responses to lignin biosynthesis perturbations in Arabidopsis.
    Plant Cell, 2012. 24(9): p. 3506-29
    [PMID:23012438]
  12. Vanholme R, et al.
    Caffeoyl shikimate esterase (CSE) is an enzyme in the lignin biosynthetic pathway in Arabidopsis.
    Science, 2013. 341(6150): p. 1103-6
    [PMID:23950498]
  13. Smith RA, et al.
    Neighboring parenchyma cells contribute to Arabidopsis xylem lignification, while lignification of interfascicular fibers is cell autonomous.
    Plant Cell, 2013. 25(10): p. 3988-99
    [PMID:24096341]
  14. Fernández-Pérez F,Vivar T,Pomar F,Pedreño MA,Novo-Uzal E
    Peroxidase 4 is involved in syringyl lignin formation in Arabidopsis thaliana.
    J. Plant Physiol., 2015. 175: p. 86-94
    [PMID:25506770]
  15. Xue J, et al.
    CCR1, an enzyme required for lignin biosynthesis in Arabidopsis, mediates cell proliferation exit for leaf development.
    Plant J., 2015. 83(3): p. 375-87
    [PMID:26058952]
  16. Jaini R,Wang P,Dudareva N,Chapple C,Morgan JA
    Targeted Metabolomics of the Phenylpropanoid Pathway in Arabidopsis thaliana using Reversed Phase Liquid Chromatography Coupled with Tandem Mass Spectrometry.
    Phytochem Anal, 2017. 28(4): p. 267-276
    [PMID:28146307]
  17. De Meester B, et al.
    Vessel-Specific Reintroduction of CINNAMOYL-COA REDUCTASE1 (CCR1) in Dwarfed ccr1 Mutants Restores Vessel and Xylary Fiber Integrity and Increases Biomass.
    Plant Physiol., 2018. 176(1): p. 611-633
    [PMID:29158331]
  18. Lacombe E, et al.
    Cinnamoyl CoA reductase, the first committed enzyme of the lignin branch biosynthetic pathway: cloning, expression and phylogenetic relationships.
    Plant J., 1997. 11(3): p. 429-41
    [PMID:9107033]