PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000290409
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family CAMTA
Protein Properties Length: 1153aa    MW: 129397 Da    PI: 5.9463
Description CAMTA family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000290409genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1CG-1179.53.9e-56651812118
           CG-1   2 lkekkrwlkneeiaaiLenfekheltlelktrpksgsliLynrkkvryfrkDGyswkkkkdgktvrEdhekLKvggvevlycyYahseenptfqrr 97 
                    l+ k+rwl++ ei++iL+n++k+++++ ++++p+ gsl+L++rk++ryfrkDG++w+kkkdgktv+E+he+LK g+v+vl+cyYah+een++fqrr
  MDP0000290409  65 LEAKHRWLRPAEICEILQNYQKFQIASVPANKPPGGSLFLFDRKVLRYFRKDGHNWRKKKDGKTVKEAHERLKAGSVDVLHCYYAHGEENENFQRR 160
                    6679******************************************************************************************** PP

           CG-1  98 cywlLeeelekivlvhylevk 118
                    +yw+Lee+l++ivlvhy+evk
  MDP0000290409 161 SYWMLEEALQHIVLVHYREVK 181
                    ******************986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5143782.29260186IPR005559CG-1 DNA-binding domain
SMARTSM010761.8E-7863181IPR005559CG-1 DNA-binding domain
PfamPF038591.3E-4966179IPR005559CG-1 DNA-binding domain
Gene3DG3DSA:2.60.40.101.7E-5565651IPR013783Immunoglobulin-like fold
SuperFamilySSF812966.47E-18566651IPR014756Immunoglobulin E-set
PfamPF018331.9E-7566650IPR002909IPT domain
Gene3DG3DSA:1.25.40.205.0E-16748861IPR020683Ankyrin repeat-containing domain
PROSITE profilePS5029716.839749860IPR020683Ankyrin repeat-containing domain
CDDcd002045.00E-12749858No hitNo description
SuperFamilySSF484031.76E-15751861IPR020683Ankyrin repeat-containing domain
SMARTSM002480.01799828IPR002110Ankyrin repeat
PROSITE profilePS500889.618799831IPR002110Ankyrin repeat
SMARTSM002481000838867IPR002110Ankyrin repeat
SuperFamilySSF525401.17E-79691024IPR027417P-loop containing nucleoside triphosphate hydrolase
SMARTSM0001514973995IPR000048IQ motif, EF-hand binding site
PROSITE profilePS500967.3649751003IPR000048IQ motif, EF-hand binding site
PfamPF006120.053976994IPR000048IQ motif, EF-hand binding site
SMARTSM000150.0219961018IPR000048IQ motif, EF-hand binding site
PROSITE profilePS500969.4329971021IPR000048IQ motif, EF-hand binding site
PfamPF006120.00139991018IPR000048IQ motif, EF-hand binding site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009409Biological Processresponse to cold
GO:0010150Biological Processleaf senescence
GO:0042742Biological Processdefense response to bacterium
GO:0050832Biological Processdefense response to fungus
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0005516Molecular Functioncalmodulin binding
Sequence ? help Back to Top
Protein Sequence    Length: 1153 aa     Download sequence    Send to blast
MWLTKLLVVG PRQSSSHAFT ISLYAQTSCV RGLSXSESLT THIEFMEETK RYGLGNQLDI  60
AQILLEAKHR WLRPAEICEI LQNYQKFQIA SVPANKPPGG SLFLFDRKVL RYFRKDGHNW  120
RKKKDGKTVK EAHERLKAGS VDVLHCYYAH GEENENFQRR SYWMLEEALQ HIVLVHYREV  180
KGNRTNYNHI QGTEEGVPYS HETEEVALNS EMDNSVSSSF NPSSFQMRSQ ATDATSLSSA  240
QASEFEDAES VYNHQASSQL QPFLELLQPK AEKTNAGVST AFYPMSFSNE YQEKLSAIPG  300
VNFSSHTQAY RKEDVKDAGV TYDPRKNLNS TLWDGALGNF TTGFQPLPFQ PXISATHSDS  360
TGIISKQENE TFGHLFTNNF GKKQMYEDRP RVQQGWQTLE ANSSGSSSWP VDQNLHSNTA  420
YDVSTRLYEG VHASNLLNSL VCHXDSDKTN DYSMPNDLQI QPSNPEQEYH LKSISKRNET  480
IEGSYKHAFA TKPLLDEGLK KLDSFNRWMS KELGDVDETQ TQSNSETYWD TVESENGVDE  540
SSVPLQVRLD SYMLGPSLSQ DQLFSIIDFS PNWAYENSEI KVLITGRFLK SQEAESCKWS  600
CMFGEVEVPA EVIADGVLRC YTPIHKAGRI PFYVTCSNRL ACSEIREFEY RVGQIPDYDA  660
KDDYTGCTNE ILNMRFGKLL SLSSSSPTFD PTSIAENSEL ISKIDLLLKN DNGEWDRMLQ  720
LTSDEDFSLE RVEDQLLQQL LKEKLRAWLL QKLAAGGKGP SVLDEGGQGV LHFGAALGYD  780
WVLLPTITAG VSVNFRDVDG WTALHWAAFH GRERTVASLI SLGAAPGLLT DPRTKYPAGR  840
TPADLASAQG HKGIAGYLAE STLSDHLSFL NLDIKEGNNA EISGAKAVET VSEQIATPIG  900
NGDLTGGLSL RDSLTAVCNA TQAAARIHQV LRVKSFQRKQ LKEFGSDNFG ISDEDALSLI  960
AVKSHKPGKR DEHVDAAAIR IQNKFRSWKG RKDYLIIRQR IVKIQAHVRG HQVRKXYRKI  1020
VWSVGIVEKI ILRWRRKGSG LRGFKPEALA EPPSMQASSS KDDDYDVLKE GRKQTEQRLQ  1080
KALARVKSMI QYPEARDQYS RLLNVVTEIQ ETKVVYDSSM NSSDGRADMD DDLVDIAALL  1140
DEDDVCMPTA APE
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2cxk_A1e-14566653991calmodulin binding transcription activator 1
2cxk_B1e-14566653991calmodulin binding transcription activator 1
2cxk_C1e-14566653991calmodulin binding transcription activator 1
2cxk_D1e-14566653991calmodulin binding transcription activator 1
2cxk_E1e-14566653991calmodulin binding transcription activator 1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.24961e-171bud| fruit| leaf
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots, stems, leaves, carpels, and siliques, but not in stigmas or other parts of the flower. {ECO:0000269|PubMed:11162426, ECO:0000269|PubMed:12218065, ECO:0000269|PubMed:14581622}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3'. Binds calmodulin in a calcium-dependent manner in vitro (PubMed:12218065). Regulates transcriptional activity in response to calcium signals (Probable). Involved in freezing tolerance in association with CAMTA1 and CAMTA2 (PubMed:23581962). Required for the cold-induced expression of DREB1B/CBF1, DREB1C/CBF2, ZAT12 and GOLS3 (PubMed:19270186). Involved in response to cold. Contributes together with CAMTA5 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2 (PubMed:28351986). Involved together with CAMTA2 and CAMTA4 in the positive regulation of a general stress response (GSR) (PubMed:25039701). Involved in the regulation of GSR amplitude downstream of MEKK1 (PubMed:25157030). Involved in the regulation of a set of genes involved in defense responses against pathogens (PubMed:18298954). Involved in the regulation of both basal resistance and systemic acquired resistance (SAR) (PubMed:21900483). Acts as negative regulator of plant immunity (PubMed:19122675, PubMed:21900483, PubMed:22345509, PubMed:28407487). Binds to the promoter of the defense-related gene EDS1 and represses its expression (PubMed:19122675). Binds to the promoter of the defense-related gene NDR1 and represses its expression (PubMed:22345509). Involved in defense against insects (PubMed:23072934, PubMed:22371088). Required for tolerance to the generalist herbivore Trichoplusia ni, and contributes to the positive regulation of genes associated with glucosinolate metabolism (PubMed:23072934). Required for tolerance to Bradysia impatiens larvae. Mediates herbivore-induced wound response (PubMed:22371088). Required for wound-induced jasmonate accumulation (PubMed:23072934, PubMed:22371088). Involved in the regulation of ethylene-induced senescence by binding to the promoter of the senescence-inducer gene EIN3 and repressing its expression (PubMed:22345509). {ECO:0000269|PubMed:12218065, ECO:0000269|PubMed:18298954, ECO:0000269|PubMed:19122675, ECO:0000269|PubMed:19270186, ECO:0000269|PubMed:21900483, ECO:0000269|PubMed:22345509, ECO:0000269|PubMed:22371088, ECO:0000269|PubMed:23072934, ECO:0000269|PubMed:23581962, ECO:0000269|PubMed:25039701, ECO:0000269|PubMed:25157030, ECO:0000269|PubMed:28351986, ECO:0000269|PubMed:28407487, ECO:0000305|PubMed:11925432}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00042PBMTransfer from AT2G22300Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By heat shock, UVB, salt, wounding, ethylene and methyl jasmonate (PubMed:11162426, PubMed:12218065). Induced by infection with the fungal pathogen Golovinomyces cichoracearum (powdery mildew) and the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000 (PubMed:22345509). {ECO:0000269|PubMed:11162426, ECO:0000269|PubMed:12218065, ECO:0000269|PubMed:22345509}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008338581.20.0calmodulin-binding transcription activator 3 isoform X1
SwissprotQ8GSA70.0CMTA3_ARATH; Calmodulin-binding transcription activator 3
TrEMBLA0A498HVW20.0A0A498HVW2_MALDO; Uncharacterized protein
STRINGXP_008338581.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF82842735
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G22300.20.0signal responsive 1
Publications ? help Back to Top
  1. Zhang L,Du L,Shen C,Yang Y,Poovaiah BW
    Regulation of plant immunity through ubiquitin-mediated modulation of Ca(2+) -calmodulin-AtSR1/CAMTA3 signaling.
    Plant J., 2014. 78(2): p. 269-81
    [PMID:24528504]
  2. Benn G, et al.
    A key general stress response motif is regulated non-uniformly by CAMTA transcription factors.
    Plant J., 2014. 80(1): p. 82-92
    [PMID:25039701]
  3. Rahman H,Yang J,Xu YP,Munyampundu JP,Cai XZ
    Phylogeny of Plant CAMTAs and Role of AtCAMTAs in Nonhost Resistance to Xanthomonas oryzae pv. oryzae.
    Front Plant Sci, 2016. 7: p. 177
    [PMID:26973658]
  4. Benn G, et al.
    Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3.
    Proc. Natl. Acad. Sci. U.S.A., 2016. 113(31): p. 8855-60
    [PMID:27432993]
  5. Kidokoro S, et al.
    Different Cold-Signaling Pathways Function in the Responses to Rapid and Gradual Decreases in Temperature.
    Plant Cell, 2017. 29(4): p. 760-774
    [PMID:28351986]
  6. Lolle S, et al.
    Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles.
    Cell Host Microbe, 2017. 21(4): p. 518-529.e4
    [PMID:28407487]
  7. Kim YS, et al.
    CAMTA-Mediated Regulation of Salicylic Acid Immunity Pathway Genes in Arabidopsis Exposed to Low Temperature and Pathogen Infection.
    Plant Cell, 2017. 29(10): p. 2465-2477
    [PMID:28982964]
  8. Jacob F, et al.
    A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana.
    New Phytol., 2018. 217(4): p. 1667-1680
    [PMID:29226970]