PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000411393
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family HD-ZIP
Protein Properties Length: 819aa    MW: 90648.4 Da    PI: 8.0456
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000411393genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox54.81.6e-17182233354
                    --SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHH CS
       Homeobox   3 kRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRak 54 
                    +  ++t+eq+++Lee+F+ +++p+ ++r++L+++l L+ rq+k+WFqN+R++
  MDP0000411393 182 NYYRHTTEQIRRLEEFFKYCSHPDDNQRQQLSRELXLEPRQIKFWFQNKRTQ 233
                    56689*********************************************87 PP
2START79.57.8e-2645156392206
                    EEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--..-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXXHHHHHHHH CS
          START  92 qlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe.sssvvRaellpSgiliepksnghskvtwvehvdlkgrlphwllrslv 185
                      m+ ++  lsplv+ Rdf+f+Ry++q + g+wvivdvS + ++  ++ +s++ R   lpSg++i++ s g s+vtw+ehv+++++  h l+r l+
  MDP0000411393 451 DSMYEQMHILSPLVApRDFYFLRYCQQIELGTWVIVDVSHNFPKGSSSnQSQSWR---LPSGCMIKDISCGCSRVTWIEHVEVDKQA-HRLYRDLI 542
                    568999999****999**************************9998766666666...*************************9875.7******* PP

                    HHHHHHHHHHHHHHTXXXXXX CS
          START 186 ksglaegaktwvatlqrqcek 206
                     + +a ga +w  tl+r ce+
  MDP0000411393 543 CRNVAYGAERWIVTLKRMCER 563
                    *******************96 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF001546.6E-1068104IPR013765DNA recombination and repair protein RecA
PROSITE profilePS5016315.09269135IPR020587DNA recombination and repair protein RecA, monomer-monomer interface
PROSITE patternPS0032108391IPR020584DNA recombination/repair protein RecA, conserved site
Gene3DG3DSA:3.30.250.101.5E-5102126IPR023400DNA recombination and repair protein RecA, C-terminal
Gene3DG3DSA:1.10.10.601.2E-18164231IPR009057Homeodomain-like
SuperFamilySSF466891.28E-16167235IPR009057Homeodomain-like
PROSITE profilePS5007116.212177237IPR001356Homeobox domain
SMARTSM003898.1E-14179241IPR001356Homeobox domain
CDDcd000866.01E-15181233No hitNo description
PfamPF000469.0E-15183233IPR001356Homeobox domain
PROSITE profilePS5084825.976367566IPR002913START domain
CDDcd088757.27E-78371562No hitNo description
SMARTSM002342.0E-12376563IPR002913START domain
SuperFamilySSF559618.1E-23376563No hitNo description
PfamPF018521.2E-20453563IPR002913START domain
Gene3DG3DSA:3.30.530.201.0E-5454530IPR023393START-like domain
SuperFamilySSF559612.61E-15580782No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0003697Molecular Functionsingle-stranded DNA binding
GO:0005524Molecular FunctionATP binding
GO:0008094Molecular FunctionDNA-dependent ATPase activity
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 819 aa     Download sequence    Send to blast
MRSWRNFSSE AMSMILSSTG FAQSIVNEAP FFFPPFKLGG NAMLVDAEHA FDPAYSKALG  60
VDVENLIIGV YYGNPEVTSG GIALKFFASV RLEIRSTGKI KSLGQGRDKA LQYLRENPLL  120
LDEIEKVKLV HNGGLRGSER AAKTLLSSPF GGKVRKRMEL QGNGGASGDG REASNSRRGN  180
KNYYRHTTEQ IRRLEEFFKY CSHPDDNQRQ QLSRELXLEP RQIKFWFQNK RTQTQAQNES  240
ADNTVLRKDN ERIQWENYAI IKALKSVLCP TCGGPPFGEE ARQLSLQRLQ LENAYLKEEA  300
SIXNHDKVAS LLSKYIGKPP SQIESLASVV GSTLDLSCST NQGIIGSPPL NLNLTSPALA  360
YQIQEIPERE KTLMAXIAAS AMEELVSLFQ IGEPLWVKST ADGRYFLNRD DYDKLFPKAN  420
QFKTSGACVE SSKDSGVVAI NAATLVDMFL DSMYEQMHIL SPLVAPRDFY FLRYCQQIEL  480
GTWVIVDVSH NFPKGSSSNQ SQSWRLPSGC MIKDISCGCS RVTWIEHVEV DKQAHRLYRD  540
LICRNVAYGA ERWIVTLKRM CERLDCLMVE VETTLVISSE GKRSVMKLSQ RMVKNFCGML  600
SMAGKIDFPQ SSEVNNSGVR VSVRKSTETG QPHGMIVSIA TSLWLPLPSQ TVFSFFRDER  660
NRVQWDVLSN GNPVHEIANI PTGTHPGNCI SVIRQPFTPT ENNMLMLQES YTDPLGSLVV  720
YAPVDMPALN VAVSGKDSSN IPILPSGFVI SGDGRAEITG DSGHSKXGGS LLTVAFQILV  780
SSPSTSKQMN MESVATVNAL ISSTVQKIKV ALNCSSLD*
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in all cells at the 4- and 16-cell embryo stages. Expression is restricted to the protoderm from the globular stage onward. {ECO:0000269|PubMed:25564655}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems and young epidermal tissue including trichomes and stipules. Expressed in lateral root tips, the L1 layer of apical inflorescence meristems and early flower primordia, carpel and petal epidermis, stigma papillae, ovule primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor. {ECO:0000250}.
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009370612.10.0PREDICTED: homeobox-leucine zipper protein ROC8-like
SwissprotQ69T580.0ROC8_ORYSJ; Homeobox-leucine zipper protein ROC8
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A498HGL50.0A0A498HGL5_MALDO; Uncharacterized protein
STRINGXP_009370612.10.0(Pyrus x bretschneideri)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]