PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000446400
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family C2H2
Protein Properties Length: 224aa    MW: 25938.7 Da    PI: 9.5761
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000446400genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H214.69.9e-055374223
                   EETTTTEEESSHHHHHHHHHHT CS
        zf-C2H2  2 kCpdCgksFsrksnLkrHirtH 23
                   +C++C+k F r  nL+ H r H
  MDP0000446400 53 VCEICNKGFQRDQNLQLHHRGH 74
                   8******************988 PP
2zf-C2H212.30.00052128150123
                    EEETTTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                    +kC +C+k +  + + k+H++t+
  MDP0000446400 128 WKCDKCSKKYAVQLDWKVHQKTC 150
                    58*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS501579.5365274IPR007087Zinc finger, C2H2
PROSITE patternPS0002805274IPR007087Zinc finger, C2H2
SMARTSM003550.995274IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.603.6E-45474IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003559893123IPR015880Zinc finger, C2H2-like
SuperFamilySSF576672.49E-5115158No hitNo description
Gene3DG3DSA:3.30.160.603.4E-4116149IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM00355110128148IPR015880Zinc finger, C2H2-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 224 aa     Download sequence    Send to blast
MALSLICNHN SRHLRRKEIF QELQANNLEL ISNPSTEVIA LSPTTLMATN RCVCEICNKG  60
FQRDQNLQLH HRGHNLPWKL RHRTTTEVRK KVYICPEPTC VHHNPARALG DLTGIKKHFS  120
RKHGEKKWKC DKCSKKYAVQ LDWKVHQKTC GTREYKCDCG TIFSEELHMM SYATSLASTS  180
NSSRRSSRSS VTMLMTENNE LRMNWDNWIW EKIEEERGRG IAA*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5b3h_C6e-21124189369Zinc finger protein JACKDAW
5b3h_F6e-21124189369Zinc finger protein JACKDAW
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
17890KLRHRTTTEVRKK
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Strongly up-regulated during seed development. {ECO:0000269|PubMed:21571950}.
UniprotTISSUE SPECIFICITY: At 3 days post anthesis (DPA), expressed in the chalazal endosperm region. By 6 DPA, expressed in the endosperm and embryo. In fully germinated seed, strongest expression in the root tip and not detected in the cotyledons. In 4-days old seedlings, restricted to the vasculature of the cotyledons, the shoot apical meristem region, and the root tip. By 8 days, restricted to newly emerged leaves. {ECO:0000269|PubMed:21571950}.
UniprotTISSUE SPECIFICITY: Observed in vegetative tissues. Mainly expressed in hypocotyls, petioles, shoot apices, root tips, and trichomes, and, at low levels, in leaves, stems and flowers. {ECO:0000269|PubMed:25035403}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor promoting the transition to germination by regulating light and hormonal signaling during seed maturation (PubMed:21571950). Acts as a positive regulator of phytochrome and/or gibberellin action (PubMed:21571950, PubMed:25035403). {ECO:0000269|PubMed:21571950, ECO:0000269|PubMed:25035403}.
UniProtTranscription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269|PubMed:25035403}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028947656.11e-118zinc finger protein GAI-ASSOCIATED FACTOR 1-like
SwissprotQ9LVQ72e-81IDD1_ARATH; Zinc finger protein ENHYDROUS
SwissprotQ9SCQ61e-81IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBLA0A3N7FC779e-90A0A3N7FC77_POPTR; Uncharacterized protein
STRINGXP_008386763.15e-90(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF18134275
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G66730.18e-72C2H2-like zinc finger protein
Publications ? help Back to Top
  1. Fukazawa J, et al.
    DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis.
    Plant Cell, 2014. 26(7): p. 2920-38
    [PMID:25035403]
  2. Moreno-Risueno MA, et al.
    Transcriptional control of tissue formation throughout root development.
    Science, 2015. 350(6259): p. 426-30
    [PMID:26494755]
  3. Khare D, et al.
    Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana.
    New Phytol., 2017. 213(3): p. 1257-1273
    [PMID:27768815]