PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MELO3C022788P1
Organism
Cucumis melo
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family C2H2
Protein Properties Length: 450aa    MW: 51964.4 Da    PI: 7.359
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MELO3C022788P1genomeMELONOMICSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.90.00069207229123
                     EEETTTTEEESSHHHHHHHHHHT CS
         zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                     y C+ C    +rk++L+rH+r++
  MELO3C022788P1 207 YFCEFCLNFMKRKEQLQRHMRKC 229
                     78*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541604.12E-2455174IPR016197Chromo domain-like
Gene3DG3DSA:2.30.30.2701.1E-3756134No hitNo description
PfamPF117171.6E-2064122IPR025995RNA binding activity-knot of a chromodomain
CDDcd000241.26E-677123No hitNo description
SMARTSM002981.6E-578137IPR000953Chromo/chromo shadow domain
Gene3DG3DSA:2.30.30.2701.1E-37168218No hitNo description
PROSITE profilePS5172675.396173444IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557297.09E-112174445IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.40.630.306.7E-73232375IPR016181Acyl-CoA N-acyltransferase
PfamPF018539.2E-84234411IPR002717Histone acetyltransferase domain, MYST-type
CDDcd043010.00138285343No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010224Biological Processresponse to UV-B
GO:0005634Cellular Componentnucleus
GO:0004402Molecular Functionhistone acetyltransferase activity
Sequence ? help Back to Top
Protein Sequence    Length: 450 aa     Download sequence    Send to blast
MGSIDVQSTS AENGSAPASS ADGRQKSLLT DGMNHISNDP DGTPPDKPKE LGPTKKRMSS  60
MLPLDVGTRV MCRWRDGKYH PVKVIERRKL QATGFSDYEY YVHYTEFNRR LDEWVKLDQL  120
DLDSVETVVD EKVEDKVTGL KMTRHQKRKI DETHVEGHEE LDAASLREHE EFTKVKNIAT  180
IELGRYEIET WYFSPFPPEY NDTTKLYFCE FCLNFMKRKE QLQRHMRKCD LKHPPGDEIY  240
RCGTLSMFEV DGKKNKVYGQ NLCYLAKLFL DHKTLYYDVD LFLFYVLCEC DDRGCHMVGY  300
FSKEKHSEES YNLACILTLP PYQRKGYGKF LIAFSYELSK KEGKVGTPER PLSDLGLVSY  360
RGYWTRVLLD ILKKHKANIS IKELSDMTAI KAEDILNTLQ SLELIQYRKG QHVICADPKV  420
LDRHLKAAGR GGLEVDVSKL IWTPYREQG*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-1161694441278Histone acetyltransferase KAT8
4dnc_B1e-1161694441278Histone acetyltransferase KAT8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:16648464, PubMed:17877703). Essential for gametophyte development (PubMed:19040736). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:16648464, ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:23273925}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818931e-178LN681893.1 Cucumis melo genomic scaffold, anchoredscaffold00055.
GenBankLN7132631e-178LN713263.1 Cucumis melo genomic chromosome, chr_9.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008460476.10.0PREDICTED: histone acetyltransferase of the MYST family 2-like isoform X1
SwissprotQ9LXD70.0MYST2_ARATH; Histone acetyltransferase of the MYST family 2
TrEMBLA0A1S3CCN90.0A0A1S3CCN9_CUCME; Histone acetyltransferase
STRINGXP_008460476.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF70661011
Publications ? help Back to Top
  1. Kerschen A,Napoli CA,Jorgensen RA,Müller AE
    Effectiveness of RNA interference in transgenic plants.
    FEBS Lett., 2004. 566(1-3): p. 223-8
    [PMID:15147899]
  2. Earley K, et al.
    Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance.
    Genes Dev., 2006. 20(10): p. 1283-93
    [PMID:16648464]
  3. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  4. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  5. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  6. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  7. Falcone Ferreyra ML, et al.
    AtPDCD5 Plays a Role in Programmed Cell Death after UV-B Exposure in Arabidopsis.
    Plant Physiol., 2016. 170(4): p. 2444-60
    [PMID:26884483]
  8. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  9. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]