PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.18G072700.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family C2H2
Protein Properties Length: 428aa    MW: 49389.5 Da    PI: 7.0066
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.18G072700.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H2120.00065185207123
                          EEETTTTEEESSHHHHHHHHHHT CS
              zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                          y C+ C    +rk++L+rH+r++
  Manes.18G072700.1.p 185 YFCEFCLNFMKRKEQLQRHMRKC 207
                          78*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541606.04E-2153152IPR016197Chromo domain-like
Gene3DG3DSA:2.30.30.2703.3E-3858196No hitNo description
PfamPF117178.0E-2162120IPR025995RNA binding activity-knot of a chromodomain
CDDcd000241.39E-675121No hitNo description
SMARTSM002981.2E-476135IPR000953Chromo/chromo shadow domain
PROSITE profilePS5172675.543151422IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557293.36E-111152423IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.40.630.305.3E-73210353IPR016181Acyl-CoA N-acyltransferase
PfamPF018534.1E-84212389IPR002717Histone acetyltransferase domain, MYST-type
CDDcd043010.00139263321No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010224Biological Processresponse to UV-B
GO:2000028Biological Processregulation of photoperiodism, flowering
GO:0005634Cellular Componentnucleus
GO:0043995Molecular Functionhistone acetyltransferase activity (H4-K5 specific)
Sequence ? help Back to Top
Protein Sequence    Length: 428 aa     Download sequence    Send to blast
MGSIETPTNP ENGSATLSPA VTAADLHQKP HSAVNGTPPQ AAEMTQMESD SLKKRRSSVL  60
PLEVGTRVMC RWRDGKYHQV KVIERRKMQC GGPNDYEYYV HYTEFNRRLD EWVKLEQLDL  120
DSVETVVDEK VEDKGHEELD AASLREHEEF TKVKNIATIE LGRYEIETWY FSPFPPEYND  180
SVKLYFCEFC LNFMKRKEQL QRHMRKCDLK HPPGDEIYRS GTLSMFEVDG KKNKVYGQNL  240
CYLAKLFLDH KTLYYDVDLF LFYILCECDD RGCHMVGYFS KEKHSEESYN LACILTLPPY  300
QRKGYGKFLI AFSYELSKKE GKVGTPERPL SDLGLLSYRG YWTRVLLDIL KKHKGNISIK  360
ELSDMTAIKA EDILTTLQSL ELIQYRKGQH VICADPKVLD RHLKAAGRGG LEVDVSKLIW  420
TPYKEQG*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-1191474261282Histone acetyltransferase KAT8
4dnc_B1e-1191474261282Histone acetyltransferase KAT8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:22170978, ECO:0000269|PubMed:23273925}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.18G072700.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021601663.10.0histone acetyltransferase of the MYST family 1-like
SwissprotQ9FLF70.0MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBLA0A2C9U1C50.0A0A2C9U1C5_MANES; Histone acetyltransferase
STRINGXP_002513838.10.0(Ricinus communis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF70661011
Publications ? help Back to Top
  1. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  2. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  3. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  4. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  5. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  6. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]