PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.18G072700.2.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family C2H2
Protein Properties Length: 311aa    MW: 36296.9 Da    PI: 7.9491
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.18G072700.2.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H212.50.000446890123
                         EEETTTTEEESSHHHHHHHHHHT CS
              zf-C2H2  1 ykCpdCgksFsrksnLkrHirtH 23
                         y C+ C    +rk++L+rH+r++
  Manes.18G072700.2.p 68 YFCEFCLNFMKRKEQLQRHMRKC 90
                         78*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5172675.54334305IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557291.16E-11135306IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.30.60.604.3E-253991No hitNo description
Gene3DG3DSA:3.40.630.302.6E-7393236IPR016181Acyl-CoA N-acyltransferase
PfamPF018531.8E-8495272IPR002717Histone acetyltransferase domain, MYST-type
CDDcd043010.0017146204No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010224Biological Processresponse to UV-B
GO:2000028Biological Processregulation of photoperiodism, flowering
GO:0005634Cellular Componentnucleus
GO:0043995Molecular Functionhistone acetyltransferase activity (H4-K5 specific)
Sequence ? help Back to Top
Protein Sequence    Length: 311 aa     Download sequence    Send to blast
MVVFEFYTRK LSFYNLQGHE ELDAASLREH EEFTKVKNIA TIELGRYEIE TWYFSPFPPE  60
YNDSVKLYFC EFCLNFMKRK EQLQRHMRKC DLKHPPGDEI YRSGTLSMFE VDGKKNKVYG  120
QNLCYLAKLF LDHKTLYYDV DLFLFYILCE CDDRGCHMVG YFSKEKHSEE SYNLACILTL  180
PPYQRKGYGK FLIAFSYELS KKEGKVGTPE RPLSDLGLLS YRGYWTRVLL DILKKHKGNI  240
SIKELSDMTA IKAEDILTTL QSLELIQYRK GQHVICADPK VLDRHLKAAG RGGLEVDVSK  300
LIWTPYKEQG *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-120303091282Histone acetyltransferase KAT8
4dnc_B1e-120303091282Histone acetyltransferase KAT8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:22170978, ECO:0000269|PubMed:23273925}.
UniProtHistone acetyltransferase which may be involved in transcriptional activation. {ECO:0000250|UniProtKB:Q9LXD7}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.18G072700.2.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021601663.10.0histone acetyltransferase of the MYST family 1-like
SwissprotQ8LI340.0MYST1_ORYSJ; Putative MYST-like histone acetyltransferase 1
SwissprotQ9FLF70.0MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBLA0A2C9U1K30.0A0A2C9U1K3_MANES; Histone acetyltransferase
STRINGVIT_18s0001g04100.t010.0(Vitis vinifera)
STRINGcassava4.1_012443m0.0(Manihot esculenta)
Publications ? help Back to Top
  1. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  2. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  3. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  4. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  5. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  6. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]