PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr3g113800.1
Common NameMTR_3g113800
Organism
Medicago truncatula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family E2F/DP
Protein Properties Length: 364aa    MW: 40883.2 Da    PI: 7.6103
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr3g113800.1genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.9e-27102167171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                      r+++sL+llt+kf++l++++++g+++ln+ a+ L   +v  ++RRiYDi+NVLe+++liek++kn+irwkg
  Medtr3g113800.1 102 RYDSSLGLLTKKFISLINEAKDGTLDLNKTAEIL---KV--QKRRIYDITNVLEGIGLIEKTSKNHIRWKG 167
                      6899******************************...88..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.5E-28100168IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.23E-18101165IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.7E-36102167IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.6E-25104167IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146604.41E-31179285No hitNo description
SuperFamilySSF1440744.71E-24179284No hitNo description
PfamPF164211.8E-22183282IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 364 aa     Download sequence    Send to blast
MSTPSEDQIP HFSQFNFTPF TSSSSSMFPL SQRNEINNVN LHTSSNVEAF PSQSNTVNLP  60
PLLQTQPNPR GKHNGKSKVS KNSKSANQIS NTDSLNSATV NRYDSSLGLL TKKFISLINE  120
AKDGTLDLNK TAEILKVQKR RIYDITNVLE GIGLIEKTSK NHIRWKGCDG LEPRELEHQV  180
NTLKDEVDSL YAEEFKLDQC ISERKELIRN LEEGENTGKY LFFTKEDILT LPCFQNKQLI  240
TIKAPKASFI EVPDPDEELG FHQRQYRMIV RSATGPINLY LLNKHDHKFE GVSAKQAKLE  300
DPSRNSNGCR MDGVGLLENQ GFQKNPSGSL NSLDSEAFGI QQITLRIWML TVIIGFNQIP  360
KLA*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-2598168374PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1134140LKVQKRR
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected at the G1/S transition, but increases during the progression into S phase and peaks after the passage into G2. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:12468727}.
UniprotTISSUE SPECIFICITY: Expressed in meristematic areas, vascular tissues, apical part of the roots, cotyledons, upper region of the hypocotyls, trichomes, young flower buds and pollen grains. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782}.
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr3g113800.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024633944.10.0LOW QUALITY PROTEIN: transcription factor E2FC
SwissprotQ9FV701e-79E2FC_ARATH; Transcription factor E2FC
TrEMBLG7J4Q90.0G7J4Q9_MEDTR; E2F transcription factor
STRINGAES740000.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF118852529
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.27e-81E2F/DP family protein
Publications ? help Back to Top
  1. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  2. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  3. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  4. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]