PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr7g427700.1
Common NameMTR_7g427700
Organism
Medicago truncatula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family HD-ZIP
Protein Properties Length: 436aa    MW: 48338.8 Da    PI: 6.1844
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr7g427700.1genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox566.6e-182272656
                     S--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
         Homeobox  6 tftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                     ++t++q+++Le++F+ ++yp++++r +L ++l ++ +++k+WFqNrR++ k
  Medtr7g427700.1 22 RHTSNQIQRLEAVFKTCSYPDEKQRLQLGRELAMDPTKIKFWFQNRRTQLK 72
                     689********************************************9987 PP
2START30.21e-10163275289
                      HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGG.....CT-TT-S... CS
            START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddke.....qWdetla... 77 
                      +a  a+qel+ +++ +ep+W+ks     + +n +++ + f+++++       ++ea+r sg v+m++ +lve ++d        +W e ++   
  Medtr7g427700.1 163 IATNAMQELIFLMETNEPLWMKSNnngrDTLNLETYETMFPRTNNqlknpnIRIEASRKSGDVIMNALTLVEMFMDPIDfveqhKWMELFPtiv 256
                      56789*******************9999999999999999999999****99***********************9988999999999999999 PP

                      .EEEEEEEECTT......E CS
            START  78 .kaetlevissg......g 89 
                        a+t+eviss       g
  Medtr7g427700.1 257 tIAKTIEVISSRtkdgldG 275
                      999******9875555555 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466891.5E-171076IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.602.3E-181178IPR009057Homeodomain-like
PROSITE profilePS5007115.8561474IPR001356Homeobox domain
SMARTSM003898.1E-161478IPR001356Homeobox domain
CDDcd000868.63E-151575No hitNo description
PfamPF000461.4E-152272IPR001356Homeobox domain
PROSITE profilePS5084817.767153269IPR002913START domain
SuperFamilySSF559611.32E-8156270No hitNo description
PfamPF018524.2E-6163275IPR002913START domain
SuperFamilySSF559611.32E-8303409No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 436 aa     Download sequence    Send to blast
MEHHSEGSVS SDTHKRKKCC NRHTSNQIQR LEAVFKTCSY PDEKQRLQLG RELAMDPTKI  60
KFWFQNRRTQ LKTQNERDDN CTLIQENDKI RSQNKAMREA LQNVICSTCD GQKLRIENAR  120
LKEELVRVSS IAAGYTGSSS TLPNVPYQPA GLSHKEKSLM FDIATNAMQE LIFLMETNEP  180
LWMKSNNNGR DTLNLETYET MFPRTNNQLK NPNIRIEASR KSGDVIMNAL TLVEMFMDPI  240
DFVEQHKWME LFPTIVTIAK TIEVISSRTK DGLDGSLQLS NVLSNGNDVQ EVVHIANVSR  300
PGNCISVFKG FSTGNNNMLI LQESCVDSSG SLVVSCPIDS SIMSEADPSY IQLLPSGFII  360
TSDGKQNENN IQGGNSGNDD VASTSSNTNI GGSLLTVAFQ IMVNSLPSKM ESVPVVNGLI  420
CKTVEQIKAA LNCPM*
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in all cells at the 4- and 16-cell embryo stages. Expression is restricted to the protoderm from the globular stage onward. {ECO:0000269|PubMed:25564655}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems and young epidermal tissue including trichomes and stipules. Expressed in lateral root tips, the L1 layer of apical inflorescence meristems and early flower primordia, carpel and petal epidermis, stigma papillae, ovule primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr7g427700.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024626568.10.0homeobox-leucine zipper protein HDG12
SwissprotQ9FX315e-79HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A072TWZ90.0A0A072TWZ9_MEDTR; Homeobox leucine zipper protein
STRINGAES783300.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF2115934
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.12e-81homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  3. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  4. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  5. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  6. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  7. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  8. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  9. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  10. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  11. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]