PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID NNU_012009-RA
Organism
Nelumbo nucifera
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Proteales; Nelumbonaceae; Nelumbo
Family bHLH
Protein Properties Length: 424aa    MW: 47547.8 Da    PI: 5.3551
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
NNU_012009-RAgenomeCASView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH40.16.7e-13209260155
                    CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
            HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                    +r++h ++Er+RR+++N+ +  Lr+l+P++   + ++ + a+i   A+e++++L+
  NNU_012009-RA 209 QRMTHIAVERNRRKQMNEHLRVLRSLMPSS---YVQRGDQASIIGGAIEFVRELE 260
                    79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.107.4E-14207263IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.10E-13207264No hitNo description
PROSITE profilePS5088815.288208259IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.57E-16208276IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.4E-10209260IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.0E-9214265IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS516718.558346424IPR002912ACT domain
SuperFamilySSF550218.7E-5346411No hitNo description
CDDcd048731.27E-4346410No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 424 aa     Download sequence    Send to blast
MAMFYLKPQL LQAGLPTGFT GLDYPLDHYH HPLKQRFGDQ NSGDNNTGMV DYMLNNPPPP  60
QMSSGFCSAT SLDRLSFAEV MQFADFGPKL AVNQAKLSDE ENGIDPGYFL KFPVLNDKLQ  120
DQSLFINPPP TANEEEKFKA IGNVAESKLT MAPDQEEEVE EEGRVSENNS VQLHILVGNN  180
SQTKSPGAEA KNRRKRPRTV KTSEEVESQR MTHIAVERNR RKQMNEHLRV LRSLMPSSYV  240
QRGDQASIIG GAIEFVRELE QLLQCLESQK RRRLYGNGTE PPRPVDDTPS LAIQQPQPPF  300
FPPLPAFPND QMKLAEFEAA GLREETAENK TCLADVEVKL LGFDAMIKIL SRRRPGQLLK  360
TIAALEDLQL NILHTNITTI EQTVLYSFNV KVASESRFTA EDIASSVQQI FNFIHASTTT  420
TTTI
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1209220RMTHIAVERNRR
2269273KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010264103.10.0PREDICTED: transcription factor FAMA-like isoform X1
SwissprotQ56YJ81e-142FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A1U8ABE60.0A0A1U8ABE6_NELNU; transcription factor FAMA-like isoform X1
STRINGXP_010264103.10.0(Nelumbo nucifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-127bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]