PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID NNU_014660-RA
Organism
Nelumbo nucifera
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Proteales; Nelumbonaceae; Nelumbo
Family HD-ZIP
Protein Properties Length: 706aa    MW: 78101.7 Da    PI: 6.2561
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
NNU_014660-RAgenomeCASView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox65.57.2e-212277156
                   TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
       Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                   +++ +++t+ q+++Le++F+++++p++++r +L++ lgL+ rq+k+WFqNrR+++k
  NNU_014660-RA 22 KKRYHRHTARQIQALEAMFKECPHPDEKQRMQLSRDLGLEPRQIKFWFQNRRTQMK 77
                   688899***********************************************998 PP
2START174.75.6e-552194422206
                    HHHHHHHHHHHHHHHC-TT-EEEE.......EXCCTTEEEEEEESSS...SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEEEE CS
          START   2 laeeaaqelvkkalaeepgWvkss.......esengdevlqkfeeskv..dsgealrasgvvdmvlallveellddkeqWdetla....kaetlev 84 
                    +a  a++el+++ + +ep+W+ks        + en++ +  ++ + k+   ++ea+r+sgvv+m+   lv  +++++ +W e ++    ka t+ev
  NNU_014660-RA 219 IAANALDELIRLLQTDEPLWMKSTtdgrdvlDLENYERTFPRPNRMKNpnVQIEASRDSGVVIMNGLALVDMFMNSN-KWVELFPtivsKARTVEV 313
                    788999******************999977766666666666666555999**************************.******99999******* PP

                    ECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE-- CS
          START  85 issg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehvdlk 173
                    +ssg      g lql++aelq+lsplv+ R+ +f+Ry++q ++g w+ivdvS ds ++++   s+  +++lpSg+li++++ng+sk+ wveh++l+
  NNU_014660-RA 314 LSSGmignrsGSLQLIYAELQVLSPLVStRELYFLRYCEQIEQGLWAIVDVSFDSSRENQ-FLSSSHCRRLPSGCLIQDMPNGYSKISWVEHMELE 408
                    ***********************************************************9.68888889*************************** PP

                    SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
          START 174 grlp.hwllrslvksglaegaktwvatlqrqcek 206
                    +++  h l+r lv sg+a+ga +w+atlqr ce+
  NNU_014660-RA 409 EKTStHRLYRDLVYSGMAFGAERWLATLQRMCER 442
                    **999***************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466894.6E-201582IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.605.3E-231783IPR009057Homeodomain-like
PROSITE profilePS5007117.7341979IPR001356Homeobox domain
SMARTSM003892.6E-192083IPR001356Homeobox domain
CDDcd000861.96E-182180No hitNo description
PfamPF000462.2E-182277IPR001356Homeobox domain
PROSITE patternPS0002705477IPR017970Homeobox, conserved site
PROSITE profilePS5084847.882209445IPR002913START domain
SuperFamilySSF559611.13E-34210443No hitNo description
CDDcd088754.17E-121213441No hitNo description
SMARTSM002341.5E-47218442IPR002913START domain
PfamPF018522.4E-47219442IPR002913START domain
Gene3DG3DSA:3.30.530.204.1E-5271399IPR023393START-like domain
SuperFamilySSF559611.15E-21464698No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 706 aa     Download sequence    Send to blast
MESDTRGSGS GEDLDASDPQ RKKRYHRHTA RQIQALEAMF KECPHPDEKQ RMQLSRDLGL  60
EPRQIKFWFQ NRRTQMKAQH ERADNCALRA ENDKIRCENI AIREALKNVI CPSCGGPPVG  120
DDMYFDEQKL RMENARLREE LDRVSSIAAK YIGRPISQLP TIQPIPVSSL DLSVGSFGGQ  180
GMVGPSLDLD LLPGSSSVPQ FPFQTVVISE MDKPLMAEIA ANALDELIRL LQTDEPLWMK  240
STTDGRDVLD LENYERTFPR PNRMKNPNVQ IEASRDSGVV IMNGLALVDM FMNSNKWVEL  300
FPTIVSKART VEVLSSGMIG NRSGSLQLIY AELQVLSPLV STRELYFLRY CEQIEQGLWA  360
IVDVSFDSSR ENQFLSSSHC RRLPSGCLIQ DMPNGYSKIS WVEHMELEEK TSTHRLYRDL  420
VYSGMAFGAE RWLATLQRMC ERFACQMVTS TSARDLGGVI PSAEGRRSMM KLAQRMINSF  480
CASISASNGH RWTTLSGLND IGVRVTVHKS TEAGQPNGVV LSATTSIWLP VSPQNVFNFF  540
RDERTRAQWD VLSNGNSVQE VAHIANGSHP GNCISVLRAF NASQNNMLIL QESCTDSSGS  600
LVVYSPVDLT AINIAMSGED PSHISLLPSG FTISPDGQLD QVMGASTSSL QGSMSKSSGS  660
LITVAFQILV SSLPSAKLNL ESVTTVNNLI STTVQQIKAA LNCPSS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010268321.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like isoform X1
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A1U8AQ320.0A0A1U8AQ32_NELNU; homeobox-leucine zipper protein HDG11-like isoform X1
STRINGXP_010268321.10.0(Nelumbo nucifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]