PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID NNU_019107-RA
Organism
Nelumbo nucifera
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Proteales; Nelumbonaceae; Nelumbo
Family bHLH
Protein Properties Length: 598aa    MW: 66324.1 Da    PI: 7.0538
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
NNU_019107-RAgenomeCASView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH391.4e-12419464454
                    HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
            HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                    +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  NNU_019107-RA 419 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAIAYINEL 464
                    799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142152.5E-5666244IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.111415464IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474595.1E-18418488IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.44E-14418469No hitNo description
Gene3DG3DSA:4.10.280.102.8E-18419485IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000105.1E-10419464IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.5E-16421470IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 598 aa     Download sequence    Send to blast
MTEYRLPVMN LWTDDNASMM EAFMASDLSQ FSWAPTASAS TTTTATDPSR TTNQSQTSMF  60
FNQDTLQQRL QTLIEGARES WTYAIFWQSS VDMSGASLLG WGDGYYKGEE DKMKRRVTVS  120
PAEQEHRKKV LRELNSLISG VPASADEPVD EEVTDTEWFF LVSMTQSFIN GSGLPGQAFF  180
ASSPVWLAGG ERLASSSCER ARQGQIFGLR TMVCIPSANG VVELGSTELI FHSSDLMNKV  240
RVLFNFNNNN SDMGPWSTTI SVQTQHQNHH HQQQTQSFFT RELNFSEFGY EGSSARNGSA  300
QSCKPESGEI LNYGERKKNS CSANGNLFSN NSQQFVADDK KKRSASSKGG NNEGMLSFTS  360
GVVLPSSCVV KSSGGTADSD QSDLDASVRE AESSRVGEPE KRPRKRGRKP ANGREEPLNH  420
VEAERQRREK LNQRFYALRA VVPNVSKMDK ASLLGDAIAY INELRTKLQA AESNKEGLQS  480
QVDSLKKELA ASRYSGSPPQ ADQDLKISNH QVSKLLDMEI EVKILGWEAM IRIQCNKKNH  540
PAARLMTALK ELDLDVHYAS VSVVKDLMIQ QATVKMSSRV YTQEQLRIAL SSKVGDAR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A9e-79612474195Transcription factor MYC3
4rqw_B9e-79612474195Transcription factor MYC3
4rs9_A9e-79612474195Transcription factor MYC3
4yz6_A9e-79612474195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1400408KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028062859.10.0transcription factor MYC2-like
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A167V6B90.0A0A167V6B9_CAMSI; MYC2 trancriptor
STRINGXP_002519814.10.0(Ricinus communis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G17880.11e-178bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]