PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID NNU_025179-RA
Organism
Nelumbo nucifera
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Proteales; Nelumbonaceae; Nelumbo
Family bHLH
Protein Properties Length: 440aa    MW: 49013.5 Da    PI: 4.9779
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
NNU_025179-RAgenomeCASView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH322.2e-10199269154
                    CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC....................TTS-STCHHHHHHHHHHHHHH CS
            HLH   1 rrrahnerErrRRdriNsafeeLrellPkas.................kapskKlsKaeiLekAveYIksL 54 
                    +r++h ++Er+RR+++N+ +  Lr+l+P+++                  + +   + a+i   A+e++++L
  NNU_025179-RA 199 QRMTHIAVERNRRKQMNEHLRVLRSLMPSSYvqrlglnpgqelmvqafVPVNLQGDQASIIGGAIEFVREL 269
                    79***************************655888888888888877766777777777777777777776 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.0E-12197273IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.09E-9197274No hitNo description
SuperFamilySSF474591.57E-13198286IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088813.827198269IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.4E-7199269IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.9E-5204275IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF550215.04E-5354420No hitNo description
CDDcd048731.00E-4354418No hitNo description
PROSITE profilePS516719.025354429IPR002912ACT domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008152Biological Processmetabolic process
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 440 aa     Download sequence    Send to blast
MDRGESYSAA LPTSFTGLDY TLDHHHQLMK PRLGENSGDG SVGMVDYMLN NPPLHQLSSG  60
FCSATSLDRL SFAEVMQFAD FGPKLALNQA KISDDENGID PGYFLKFPVL NDKLQDQSLL  120
IPPPTTEEEE ERFKMPNAES KVTVAGEEEV EEEGRVVSEN NSVQLHTPGG NLQKSPGAEA  180
KSRRKRPRTV KTSEEVESQR MTHIAVERNR RKQMNEHLRV LRSLMPSSYV QRLGLNPGQE  240
LMVQAFVPVN LQGDQASIIG GAIEFVRELE QLLQCLESQK RRRLYGSGEE PPRPIGDSPP  300
LAIQQPQLPF LPPLPLSNDQ MKLVELETGL REETAENKSC LAEVEVKLLG FDAMIKILSQ  360
RRPGQLLKTI AALEDLQLNI LHTNITTIEQ TVLYSFNVKV ASESRFSAEE IASSVQQIFN  420
FIHANTTTTT TTPTTTMQSC
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1199210RMTHIAVERNRR
2279283KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010245996.10.0PREDICTED: transcription factor FAMA-like
SwissprotQ56YJ81e-136FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A1U7Z1R30.0A0A1U7Z1R3_NELNU; transcription factor FAMA-like
STRINGXP_010245996.10.0(Nelumbo nucifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-119bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]