PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_22734_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family bHLH
Protein Properties Length: 505aa    MW: 55410.9 Da    PI: 6.5956
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_22734_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.69.1e-13325370454
                     HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
             HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                     +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  Neem_22734_f_1 325 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAISYINEL 370
                     799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142151.2E-21382IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.39321370IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.09E-15324375No hitNo description
SuperFamilySSF474596.54E-19324391IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.9E-10325370IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.105.6E-19325391IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.3E-17327376IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 505 aa     Download sequence    Send to blast
MTQSFYVNGG GLPAQAFFSN SPVWVCGSER LVHSSCERAR QGQVFGLQTI VCIPSANGVV  60
ELGSTDMIIQ SADLMNKVRF LFNFNSMEIG SWPSIQNQDQ GENDPSSWIN DPTPGFVEIK  120
DSAAAVGSGP GSVSAANNNN HLQISKGIQL ENPRPASLTE NVSGVDLQQQ QNQQIQQTQS  180
LFSRELNFSE YGYDHSSVRN GNSHLLKPES GEILNFAESK RSSTANGNNN LFSNHSPFVA  240
EETNKKKRSP TSRGSNEEGM LSFTSGVILP SSGVVKSSGG AGDSDHSDLE ASVVKEADSS  300
RVVDPEKRPR KRGRKPANGR EEPLNHVEAE RQRREKLNQR FYALRAVVPN VSKMDKASLL  360
GDAISYINEL KEKLQSLESD KEDMKKQLES MKKELASGAK DSRSGPSISD QELQMSNHAS  420
KLIDMDIEVK IIGWDAMIRI QCSKKNHPAA KLMAALKELD LEVHHASMSV VNDLMIQQAT  480
VKMGSRFYTQ EQLWNVLAAK VGDSL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A9e-35319396279Transcription factor MYC2
5gnj_B9e-35319396279Transcription factor MYC2
5gnj_E9e-35319396279Transcription factor MYC2
5gnj_F9e-35319396279Transcription factor MYC2
5gnj_G9e-35319396279Transcription factor MYC2
5gnj_I9e-35319396279Transcription factor MYC2
5gnj_M9e-35319396279Transcription factor MYC2
5gnj_N9e-35319396279Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1306314KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006428423.10.0transcription factor MYC2
RefseqXP_006491734.10.0transcription factor MYC2-like
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A067DP670.0A0A067DP67_CITSI; Uncharacterized protein
STRINGXP_006491734.10.0(Citrus sinensis)
STRINGXP_006428423.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM12652896
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G17880.11e-139bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]