PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Neem_3484_f_4

Organism

Azadirachta indica

Taxonomic ID

124943

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta

Family

bHLH

Protein Properties

Length: 321aa MW: 35399.9 Da PI: 10.4601

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Neem_3484_f_4	genome	NGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	35.5	1.8e-11	163	210	4	54
HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS HLH 4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 ++ rE+ RRdr+N++f eL ++l + + +K +Ka+iL Av+ + +L Neem_3484_f_4 163 SKACREKLRRDRLNDKFMELGSILEPG---RPPKTDKAAILIDAVRMVTQL 210 6789********************8...89************99988 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	12.741	159	210	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	4.6E-9	163	210	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	1.1E-12	163	232	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	4.58E-13	164	235	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	4.1E-9	165	216	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	2.11E-7	167	215	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 321 aa Download sequence Send to blast
MTFSTTLGFR PRPKLKIKIK HVPRLTRAGT PFTRTPPPAA PIPQKFHAQI PLSYSLSLSS 60 KHPVCFPGKF LTAGKTHYHF SGLKKMVSPE TTNWLLDYPL IDDITVPDGN FSVSASGFTW 120 TTPINGPSNV SVEMDSAYGD SNGLKEAGSK KRVRSESCGS SSSKACREKL RRDRLNDKFM 180 ELGSILEPGR PPKTDKAAIL IDAVRMVTQL RGEAQKLKDS NSSLQEKIKE LKAEKNELRD 240 EKQRLKAEKE KLEQQLKAMN THPSFLAPPP AIPAAAFAAQ GQAPVNKLMP FISYPGVAMW 300 QFMPPAAVDT SQDHVLRPPV A

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor. Plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. May regulate gene expression in response to metal homeostasis changes. {ECO:0000269\|PubMed:17028341}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021595307.1	1e-137	transcription factor ILR3
Swissprot	Q9FH37	1e-113	ILR3_ARATH; Transcription factor ILR3
TrEMBL	A0A2C9UE48	1e-136	A0A2C9UE48_MANES; Uncharacterized protein
STRING	cassava4.1_015179m	1e-136	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM1437	28	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G54680.1	2e-88	bHLH family protein

Publications ? help Back to Top
Li X,Zhang H,Ai Q,Liang G,Yu D Two bHLH Transcription Factors, bHLH34 and bHLH104, Regulate Iron Homeostasis in Arabidopsis thaliana. Plant Physiol., 2016. 170(4): p. 2478-93 [PMID:26921305] Aparicio F,Pallás V The coat protein of Alfalfa mosaic virus interacts and interferes with the transcriptional activity of the bHLH transcription factor ILR3 promoting salicylic acid-dependent defence signalling response. Mol. Plant Pathol., 2017. 18(2): p. 173-186 [PMID:26929142] Liang G,Zhang H,Li X,Ai Q,Yu D bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana. J. Exp. Bot., 2017. 68(7): p. 1743-1755 [PMID:28369511] Ezer D, et al. The G-Box Transcriptional Regulatory Code in Arabidopsis. Plant Physiol., 2017. 175(2): p. 628-640 [PMID:28864470] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Min JH, et al. Arabidopsis Basic Helix-Loop-Helix 34 (bHLH34) Is Involved in Glucose Signaling through Binding to a GAGA Cis-Element. Front Plant Sci, 2017. 8: p. 2100 [PMID:29321786] Samira R, et al. The bHLH transcription factor ILR3 modulates multiple stress responses in Arabidopsis. Plant Mol. Biol., 2018. 97(4-5): p. 297-309 [PMID:29882068]