PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_37436_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family E2F/DP
Protein Properties Length: 372aa    MW: 42152.6 Da    PI: 10.0693
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_37436_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.25.7e-231984171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rkeksL+ll+++flkl+++   + + l+++a++L    v  +rRRiYD++N+Le+++++++k+kn ++w+g
  Neem_37436_f_1 19 RKEKSLGLLCSNFLKLYNRDGVESIGLDDAASRL---GV--ERRRIYDVVNILESIGIVARKAKNLYSWQG 84
                    79*****************999************...**..****************************98 PP
2E2F_TDP72.54.5e-23142221271
         E2F_TDP   2 keksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     +eksL+lltq+f+kl+ +s+ +++tl+++a +L+ +      +++k RR+YDi+NV++++nliek     ++++++rw g
  Neem_37436_f_1 142 REKSLWLLTQNFVKLFLCSDVDMITLDNAAVALLGDthnstAMRTKIRRLYDIANVFSSMNLIEKihhpeSRRPAFRWLG 221
                     79***************************************************************999999999****87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.9E-251786IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.78E-161882IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.9E-271984IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-192084IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.2E-20139221IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.2E-29141221IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.86E-12143222IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.1E-17143221IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 372 aa     Download sequence    Send to blast
MSAFVFREND STGKQFYSRK EKSLGLLCSN FLKLYNRDGV ESIGLDDAAS RLGVERRRIY  60
DVVNILESIG IVARKAKNLY SWQGFDAIPE ALALLKEEGL RENFHIIGCA NSANVLNDGE  120
NGASSSTSTD GQESSSKIET KREKSLWLLT QNFVKLFLCS DVDMITLDNA AVALLGDTHN  180
STAMRTKIRR LYDIANVFSS MNLIEKIHHP ESRRPAFRWL GWRGKHSNRS ASILDLNEPK  240
KRLFGTEITN FSLKKNKVDS LTDRKSNQKL NMPTHFRHFN VENSHGENIS ELQSKKRSKG  300
FVYGPFTPVS ISGAINSTNK NAKRVEDFKT LASTFCPRYH NQALSDLFGH YIDAWKSWYA  360
EVGGKERKNQ RP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-37182133228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006446434.10.0E2F transcription factor-like E2FF
RefseqXP_024047120.10.0E2F transcription factor-like E2FF
SwissprotQ8RWL01e-122E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A2H5P3220.0A0A2H5P322_CITUN; Uncharacterized protein
STRINGXP_006446434.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-120DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]