PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_39617_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family E2F/DP
Protein Properties Length: 267aa    MW: 30143.8 Da    PI: 4.2949
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_39617_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP77.99.6e-25362771
         E2F_TDP  7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    +llt+kf++l++++++g+++ln  a+ L   +v  ++RRiYDi+NVLe+++liek++kn+irwkg
  Neem_39617_f_1  3 GLLTRKFVNLIQEAKDGTLDLNRTAEVL---EV--QKRRIYDITNVLEGIGLIEKTSKNHIRWKG 62
                    589*************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.0E-25363IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.6E-28362IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.1E-23362IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.74E-16460IPR011991Winged helix-turn-helix DNA-binding domain
CDDcd146602.57E-3773180No hitNo description
SuperFamilySSF1440748.11E-2774179No hitNo description
PfamPF164217.7E-2578177IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 267 aa     Download sequence    Send to blast
MAGLLTRKFV NLIQEAKDGT LDLNRTAEVL EVQKRRIYDI TNVLEGIGLI EKTSKNHIRW  60
KGSDCSGPRE LDDQVARLKA EIGSLYAEEC GIDNSIREKQ ELLRTLEQNE NHQKYLFLTE  120
EDISSLPCFQ NQTLIAIKAP QASYIEVPDP DEEISFLKRQ YKMTVRSTTG PIDLYLLSKY  180
ECQAEDISIQ QTKSVDASTC NCGPCGMQTP GLVSEHDDDQ KACFGTFDLM SSETSGIQKI  240
VPSDCDIDDD YWLRSDPEVS ITDLWSN
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-233621373PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006473646.11e-152transcription factor E2FC
SwissprotQ9FV708e-95E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A067HAK61e-154A0A067HAK6_CITSI; Uncharacterized protein
STRINGXP_006473646.11e-152(Citrus sinensis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.23e-97E2F/DP family protein
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]