PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_700_f_2
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family bHLH
Protein Properties Length: 430aa    MW: 47570.9 Da    PI: 6.9431
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_700_f_2genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH407.1e-13285331455
                   HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
           HLH   4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                   +h e+Er+RR+++N++f  Lr ++P+ +      K++Ka+ L  A+ YI +Lq
  Neem_700_f_2 285 NHVEAERQRREKLNQRFYALRAVVPNiS------KMDKASLLGDAITYITDLQ 331
                   799***********************66......*****************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142158.9E-4349231IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.831281330IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.02E-18284350IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.95E-14284335No hitNo description
PfamPF000102.3E-10285331IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.4E-18285351IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003535.4E-14287336IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 430 aa     Download sequence    Send to blast
MGEKFWANEE DKAMVESVLG AEACEFLISL ASNNVLADLV SPPGDLGVQP RLCQVIEGSS  60
WNYAIFWYAA SLKSGGSALI WGDGHCRDPK HGRVGGGNSS GDKKVDGVDG KQEVKKQVLQ  120
KLHACFRGLE EDNYASKLDG VSAVEMFYLT SMYFSFRCDS AYGPGEAHKS GRSIWSSGSV  180
SCLDHYQSRS YLARSSGFQT AVFVPVKSGV VELGSVKLMP EEHDVVEMIK TKLFPHMNQM  240
VVGGFDAQAR LSGLEQKDDS SPQADERKPR KRGRKPANGR EEPLNHVEAE RQRREKLNQR  300
FYALRAVVPN ISKMDKASLL GDAITYITDL QMKIRVLETE KEMVNNKQKQ IAVPEIDFQP  360
RHDDAIVRVS CPLDTHPVCS VMKAFSEHQI VAQDSNVSTT EDKVIHTFSV RTQGGGAEQL  420
KEKLVDAISK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A1e-29279353276Transcription factor MYC2
5gnj_B1e-29279353276Transcription factor MYC2
5gnj_E1e-29279353276Transcription factor MYC2
5gnj_F1e-29279353276Transcription factor MYC2
5gnj_G1e-29279353276Transcription factor MYC2
5gnj_I1e-29279353276Transcription factor MYC2
5gnj_M1e-29279353276Transcription factor MYC2
5gnj_N1e-29279353276Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1266274RKPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that negatively regulates jasmonate (JA) signaling (PubMed:30610166). Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection (PubMed:30610166). Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00099PBMTransfer from AT4G16430Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by wounding, feeding with herbivorous insects, infection with the fungal pathogen Botrytis cinerea and infection with the bacterial pathogen Pseudomonas syringae pv tomato DC3000. {ECO:0000269|PubMed:30610166}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006479569.10.0transcription factor bHLH3
RefseqXP_024044801.10.0transcription factor bHLH3
SwissprotA0A3Q7H2161e-170MTB3_SOLLC; Transcription factor MTB3
TrEMBLA0A067FM980.0A0A067FM98_CITSI; Uncharacterized protein
TrEMBLV4TUI20.0V4TUI2_9ROSI; Uncharacterized protein
STRINGXP_006479569.10.0(Citrus sinensis)
STRINGXP_006443887.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM66112741
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G16430.11e-151bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  3. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]