PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Neem_8505_f_4

Organism

Azadirachta indica

Taxonomic ID

124943

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta

Family

AP2

Protein Properties

Length: 608aa MW: 66717.8 Da PI: 7.5544

Description

AP2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Neem_8505_f_4	genome	NGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	46.6	8.5e-15	360	411	1	55
AP2 1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 s y+GV+++++ grW A+I + +k +lg+f t eeAa+a++ a+ k++g Neem_8505_f_4 360 SIYRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFSTQEEAAEAYDIAAIKFRG 411 57**************988532...5**********************997 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF00847	1.3E-9	360	411	IPR001471	AP2/ERF domain
CDD	cd00018	4.27E-25	360	421	No hit	No description
SuperFamily	SSF54171	1.83E-17	360	420	IPR016177	DNA-binding domain
Gene3D	G3DSA:3.30.730.10	1.0E-17	361	419	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	18.834	361	419	IPR001471	AP2/ERF domain
SMART	SM00380	3.9E-34	361	425	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 608 aa Download sequence Send to blast
MEVPQDLHHH NQTQPSSPAS AVIPPTAVPS GILQCLPYSF YYGLEAENSG LFSPLPVMPL 60 RSDGSLCMME ALSRSQQPQG MVTTSTPKLE DFFGGTTMGT HHYESNDREA MALSLDSMYY 120 HQNPENEPNN QNCLTHLQEN SRLQQQQQQQ QIPVQQYQYY NTDVRSHEMF PVEKGKETQV 180 ADCNLQLPTM AGDGLHGMRN WVSRNYPTEH AMQQKIIGCM SDNGGESGSV GAMPCGDLQS 240 LSLSMSPASQ SSCVTGSQQI SHAVTHRASM ETKKRGPEKV DQKKVAHRKS IDTFGQRTSQ 300 YRGIDGPVDM KLIFGTTVAR KKDKVGREGK VRGYDMEEKA ARAYDLAALK KSSGFSRGAS 360 IYRGVTRHHQ HGRWQARIGR VAGNKDLYLG TFSTQEEAAE AYDIAAIKFR GVTAVTNFDI 420 TRYDVERIMA SNTLLAGEHA RRSKEMGPVN AVSNHNPSAH NNTEIILPQN GSVPPDWKMV 480 PYPTPRQLEH KASNINIMNN CNAQSFSMAP DSVIGMDTVS SAHQEVQSSA KMGHHLSNAS 540 SLVTSLSSSR EGSPDGTSVP VPFAMPRTAS KLLTSPTATV NSWIPPATEL RPALSVPHMP 600 VFAAWTDS

Sequence ? help Back to Top

Protein Sequence Length: 608 aa Download sequence Send to blast

MEVPQDLHHH NQTQPSSPAS AVIPPTAVPS GILQCLPYSF YYGLEAENSG LFSPLPVMPL  60
RSDGSLCMME ALSRSQQPQG MVTTSTPKLE DFFGGTTMGT HHYESNDREA MALSLDSMYY  120
HQNPENEPNN QNCLTHLQEN SRLQQQQQQQ QIPVQQYQYY NTDVRSHEMF PVEKGKETQV  180
ADCNLQLPTM AGDGLHGMRN WVSRNYPTEH AMQQKIIGCM SDNGGESGSV GAMPCGDLQS  240
LSLSMSPASQ SSCVTGSQQI SHAVTHRASM ETKKRGPEKV DQKKVAHRKS IDTFGQRTSQ  300
YRGIDGPVDM KLIFGTTVAR KKDKVGREGK VRGYDMEEKA ARAYDLAALK KSSGFSRGAS  360
IYRGVTRHHQ HGRWQARIGR VAGNKDLYLG TFSTQEEAAE AYDIAAIKFR GVTAVTNFDI  420
TRYDVERIMA SNTLLAGEHA RRSKEMGPVN AVSNHNPSAH NNTEIILPQN GSVPPDWKMV  480
PYPTPRQLEH KASNINIMNN CNAQSFSMAP DSVIGMDTVS SAHQEVQSSA KMGHHLSNAS  540
SLVTSLSSSR EGSPDGTSVP VPFAMPRTAS KLLTSPTATV NSWIPPATEL RPALSVPHMP  600
VFAAWTDS

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269\|PubMed:10528263, ECO:0000269\|PubMed:10639184, ECO:0000269\|PubMed:10948255, ECO:0000269\|PubMed:11041883, ECO:0000269\|PubMed:12183381, ECO:0000269\|PubMed:12271029, ECO:0000269\|PubMed:12655002, ECO:0000269\|PubMed:8742706, ECO:0000269\|PubMed:8742707, ECO:0000269\|PubMed:9001406, ECO:0000269\|PubMed:9093862, ECO:0000269\|PubMed:9118807}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006426139.2	0.0	AP2-like ethylene-responsive transcription factor ANT
Swissprot	Q38914	1e-100	ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBL	V4UJ45	0.0	V4UJ45_9ROSI; Uncharacterized protein
STRING	XP_006426139.1	0.0	(Citrus clementina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM3137	28	63

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G37750.1	3e-69	AP2 family protein

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Horstman A,Willemsen V,Boutilier K,Heidstra R AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks. Trends Plant Sci., 2014. 19(3): p. 146-57 [PMID:24280109] Li C, et al. Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis. PLoS ONE, 2014. 9(4): p. e94830 [PMID:24756087] Wynn AN,Seaman AA,Jones AL,Franks RG Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development. Front Plant Sci, 2014. 5: p. 130 [PMID:24778638] Randall RS, et al. AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins. Biol Open, 2015. 4(10): p. 1229-36 [PMID:26340943] Meng LS,Wang ZB,Yao SQ,Liu A The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis. J. Cell. Sci., 2015. 128(21): p. 3922-32 [PMID:26395398] Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis. Plant Physiol., 2016. 170(1): p. 283-93 [PMID:26537561] Krizek BA, et al. RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways. Plant Physiol., 2016. 171(3): p. 2069-84 [PMID:27208279] Han H,Krizek BA AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels. Plant Mol. Biol., 2016. 92(4-5): p. 597-612 [PMID:27605095] Karpinska B,Alomrani SO,Foyer CH Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018. [PMID:28808105] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470]