PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Niben101Scf00046g02008.1

Organism

Nicotiana benthamiana

Taxonomic ID

4100

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

NAC

Protein Properties

Length: 358aa MW: 40187.1 Da PI: 6.3218

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Niben101Scf00046g02008.1	genome	BTI	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	101.7	1e-31	54	196	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkk...lel.eevikevd....iykvePwdLpkkvkaeekewyfFskrdkkyatgkrknra 77 lp+G++F+P+d el+ eyL++k+ + +++ +e+i+++d i++++P++Lp +k++ ++++fF + ++y+tgkrk+r+ Niben101Scf00046g02008.1 54 LPVGVKFDPSDVELL-EYLEEKCGVGNskqHKFiDEFIPTLDiyegICYTHPENLP-GAKKDGSSVHFFYRITNAYSTGKRKRRK 136 799**********.**877663343331335777775555889***.556778899**************8 PP NAM 78 ........tksgyWkatgkdkevlskkgelvglkktLvfykg..rapkgektdWvmheyrl 128 ++ +W++tgk+k v++ +g ++g+kk++v+y++ + k ekt+Wvmh+y+l Niben101Scf00046g02008.1 137 isdennliKEHVRWHKTGKTKVVME-NGLQKGCKKVMVLYQNtkKGLKQEKTHWVMHQYHL 196 6888888766999******99.999*******6522556788*******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.18E-36	39	215	IPR003441	NAC domain
PROSITE profile	PS51005	29.103	54	215	IPR003441	NAC domain
Pfam	PF02365	6.2E-14	55	196	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 358 aa Download sequence Send to blast
MGSWLIDGRG LARKIKSASA PAAHQIKDCG AKRQCPNCHY YIDNNDVSQE WPGLPVGVKF 60 DPSDVELLEY LEEKCGVGNS KQHKFIDEFI PTLDIYEGIC YTHPENLPGA KKDGSSVHFF 120 YRITNAYSTG KRKRRKISDE NNLIKEHVRW HKTGKTKVVM ENGLQKGCKK VMVLYQNTKK 180 GLKQEKTHWV MHQYHLGTDE DEKEGEYVVS KIFYQQQKQS VKPNVSRVNE EASVGANQTG 240 PTTPKMEVEI AKEPGQSSDA KVKCEMEYPT CLAGESQGAD ANDVDNSLLC DELLASYLDS 300 FEHNLGSSTE FTHNTSHLPQ GNGNTTCGIS ELDNLELDTP PDFQLAVGFA IRFSREYL

Sequence ? help Back to Top

Protein Sequence Length: 358 aa Download sequence Send to blast

MGSWLIDGRG LARKIKSASA PAAHQIKDCG AKRQCPNCHY YIDNNDVSQE WPGLPVGVKF  60
DPSDVELLEY LEEKCGVGNS KQHKFIDEFI PTLDIYEGIC YTHPENLPGA KKDGSSVHFF  120
YRITNAYSTG KRKRRKISDE NNLIKEHVRW HKTGKTKVVM ENGLQKGCKK VMVLYQNTKK  180
GLKQEKTHWV MHQYHLGTDE DEKEGEYVVS KIFYQQQKQS VKPNVSRVNE EASVGANQTG  240
PTTPKMEVEI AKEPGQSSDA KVKCEMEYPT CLAGESQGAD ANDVDNSLLC DELLASYLDS  300
FEHNLGSSTE FTHNTSHLPQ GNGNTTCGIS ELDNLELDTP PDFQLAVGFA IRFSREYL

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	130	135	KRKRRK

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009799111.1	0.0	PREDICTED: NAC domain-containing protein 8-like
Refseq	XP_016444166.1	0.0	PREDICTED: NAC domain-containing protein 8-like
Swissprot	Q6NQK2	2e-82	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A1S3XW50	0.0	A0A1S3XW50_TOBAC; NAC domain-containing protein 8-like
TrEMBL	A0A1U7YAY5	0.0	A0A1U7YAY5_NICSY; NAC domain-containing protein 8-like
STRING	XP_009799111.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA8175	22	29

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G14490.1	3e-91	NAC domain containing protein 85

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]