PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Niben101Scf04216g06004.1
Organism
Nicotiana benthamiana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family NAC
Protein Properties Length: 324aa    MW: 37746 Da    PI: 6.6419
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Niben101Scf04216g06004.1genomeBTI-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM171.42.9e-5371351128
                       NAM   1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpk...kvkaeekewyfFskrdkkyatgkrknratksgy 82 
                               +ppGfrFhPt+eelv +yLk+k+++ +++l +vi+++d+y++ePwd++      ++e++ewyfFs++d+ky+tg+r+nrat++g+
  Niben101Scf04216g06004.1   7 VPPGFRFHPTEEELVGYYLKRKINSLEIDL-DVITDIDLYRIEPWDIEGrckLGYEEQNEWYFFSHKDRKYPTGRRTNRATAAGF 90 
                               69****************************.9***************952432234677************************** PP

                       NAM  83 WkatgkdkevlskkgelvglkktLvfykgrapkgektdWvmheyrl 128
                               Wkatg+dk+vls k++ +g++ktLvfykgrap+g+k+dW+mheyrl
  Niben101Scf04216g06004.1  91 WKATGRDKAVLS-KEKIIGMRKTLVFYKGRAPNGRKSDWIMHEYRL 135
                               ************.9999***************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019411.57E-595156IPR003441NAC domain
PROSITE profilePS5100558.547156IPR003441NAC domain
PfamPF023651.4E-288135IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009735Biological Processresponse to cytokinin
GO:0009737Biological Processresponse to abscisic acid
GO:0009741Biological Processresponse to brassinosteroid
GO:0045491Biological Processxylan metabolic process
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0048759Biological Processxylem vessel member cell differentiation
GO:0050832Biological Processdefense response to fungus
GO:0071365Biological Processcellular response to auxin stimulus
GO:0090059Biological Processprotoxylem development
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0042803Molecular Functionprotein homodimerization activity
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 324 aa     Download sequence    Send to blast
MEMDSCVPPG FRFHPTEEEL VGYYLKRKIN SLEIDLDVIT DIDLYRIEPW DIEGRCKLGY  60
EEQNEWYFFS HKDRKYPTGR RTNRATAAGF WKATGRDKAV LSKEKIIGMR KTLVFYKGRA  120
PNGRKSDWIM HEYRLQSSEH APPQEEGWVV CRAFKKPTPN KQPCLDLAWQ NSYYIRGTNT  180
TYRPEISTSM HQPFNNAFNQ TTNFHQFTFN PSHDHHQNMI INSSQNYFEN QLVKLPQLDS  240
PTISTSLCTN DKSLGEQNYT GNYEDDCEEV KHNNGINNSQ YCGDWKSFDT LIKSSSNSFP  300
NPSLLTRDDS QNHINHSLDC LPDL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ut4_A3e-47715617165NO APICAL MERISTEM PROTEIN
1ut4_B3e-47715617165NO APICAL MERISTEM PROTEIN
1ut7_A3e-47715617165NO APICAL MERISTEM PROTEIN
1ut7_B3e-47715617165NO APICAL MERISTEM PROTEIN
3swm_A3e-47715620168NAC domain-containing protein 19
3swm_B3e-47715620168NAC domain-containing protein 19
3swm_C3e-47715620168NAC domain-containing protein 19
3swm_D3e-47715620168NAC domain-containing protein 19
3swp_A3e-47715620168NAC domain-containing protein 19
3swp_B3e-47715620168NAC domain-containing protein 19
3swp_C3e-47715620168NAC domain-containing protein 19
3swp_D3e-47715620168NAC domain-containing protein 19
4dul_A3e-47715617165NAC domain-containing protein 19
4dul_B3e-47715617165NAC domain-containing protein 19
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death) (PubMed:20935069, PubMed:20488898, PubMed:22037706, PubMed:21284754). Involved in xylem formation in roots and shoots, especially regulating protoxylem vessel differentiation by promoting immature xylem vessel-specific genes expression (PubMed:16103214, PubMed:18445131, PubMed:20488898, PubMed:21498679, PubMed:21284754). Can activate the expression of several genes including XCP1, MYB46, NAC010/SND3, MYB103, MYB58, MYB63, MYB83, KNAT7, ASL19 and ASL20 (PubMed:17890373, PubMed:19088331, PubMed:18952777, PubMed:19122102, PubMed:19808805, PubMed:20935069, PubMed:21284754). {ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:17890373, ECO:0000269|PubMed:18445131, ECO:0000269|PubMed:18952777, ECO:0000269|PubMed:19088331, ECO:0000269|PubMed:19122102, ECO:0000269|PubMed:19808805, ECO:0000269|PubMed:20488898, ECO:0000269|PubMed:20935069, ECO:0000269|PubMed:21284754, ECO:0000269|PubMed:21498679, ECO:0000269|PubMed:22037706}.; FUNCTION: Required for the soilborne fungal pathogen Verticillium longisporum-induced transdifferentiation of chloroplast-containing bundle sheath cells to functional xylem elements leading to stunted growth, vein clearing, and leaf chloroses, as well as xylem hyperplasia within the vasculature of leaves, hypocotyls, and roots due to reinitiation of cambial activity and transdifferentiation of xylem parenchyma cells. This developmental reprogramming mediates also an increased drought stress tolerance. {ECO:0000269|PubMed:23023171}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00017PBMTransfer from AT1G71930Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By brassinosteroids (e.g. brassinolide BL), auxin (e.g. 2,4-dichlorphenoxyacetic acid 2,4-D) and cytokinin (e.g. kinetin), with a synergistic effect (PubMed:16103214, PubMed:22345435). Up-regulated in a feed-back loop by ASL20 (PubMed:19088331). Levels are monitored by proteasome-mediated degradation (PubMed:18445131). Repressed by WEE1 upon replication stress to prevent premature tracheary element differentiation (PubMed:21498679). Accumulates during infection by the soilborne fungal pathogen Verticillium longisporum, especially in tissues undergoing de novo xylem formation (PubMed:23023171). {ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:18445131, ECO:0000269|PubMed:19088331, ECO:0000269|PubMed:21498679, ECO:0000269|PubMed:22345435, ECO:0000269|PubMed:23023171}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009801425.10.0PREDICTED: NAC domain-containing protein 7-like
RefseqXP_009801426.10.0PREDICTED: NAC domain-containing protein 7-like
RefseqXP_009801427.10.0PREDICTED: NAC domain-containing protein 7-like
RefseqXP_009801429.10.0PREDICTED: NAC domain-containing protein 7-like
RefseqXP_016441936.10.0PREDICTED: NAC domain-containing protein 30-like
SwissprotQ9C8W91e-116NAC30_ARATH; NAC domain-containing protein 30
TrEMBLA0A1S3XPT40.0A0A1S3XPT4_TOBAC; NAC domain-containing protein 30-like
TrEMBLA0A1U7YRH10.0A0A1U7YRH1_NICSY; NAC domain-containing protein 7-like
STRINGXP_009801425.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA13424297
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G71930.11e-115vascular related NAC-domain protein 7
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Kakehi J, et al.
    Mutations in ribosomal proteins, RPL4 and RACK1, suppress the phenotype of a thermospermine-deficient mutant of Arabidopsis thaliana.
    PLoS ONE, 2015. 10(1): p. e0117309
    [PMID:25625317]
  3. Li Z, et al.
    A Transcriptional and Metabolic Framework for Secondary Wall Formation in Arabidopsis.
    Plant Physiol., 2016. 172(2): p. 1334-1351
    [PMID:27566165]
  4. de Lucas M, et al.
    Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation.
    Plant Cell, 2016. 28(10): p. 2616-2631
    [PMID:27650334]
  5. Tan TT, et al.
    Transcription Factors VND1-VND3 Contribute to Cotyledon Xylem Vessel Formation.
    Plant Physiol., 2018. 176(1): p. 773-789
    [PMID:29133368]
  6. Ohashi-Ito K,Iwamoto K,Fukuda H
    LOB DOMAIN-CONTAINING PROTEIN 15 Positively Regulates Expression of VND7, a Master Regulator of Tracheary Elements.
    Plant Cell Physiol., 2018. 59(5): p. 989-996
    [PMID:29444288]