PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Ote100081250031

Organism

Ocimum tenuiflorum

Taxonomic ID

204149

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum

Family

E2F/DP

Protein Properties

Length: 428aa MW: 47808.4 Da PI: 4.657

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Ote100081250031	genome	OteDB	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	81.9	5.3e-26	101	166	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL llt+kf++l++++e+g+++ln +a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Ote100081250031\|100081250031 101 RYDSSLSLLTKKFIALIKHAEDGELDLNMAADTL---QV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 166 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.1E-27	98	168	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.41E-16	101	164	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.9E-33	101	166	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	4.1E-24	103	166	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	1.05E-25	181	256	No hit	No description
Pfam	PF16421	1.1E-23	182	260	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	4.21E-32	182	257	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 428 aa Download sequence Send to blast
MVYSPTTFVL ICNAHADFNV QIGISQPFKR KNGYQNNEVE SSELTASQAY SDIANSPFRT 60 PVAKGRANCR SKATKNNRSA PSTPISSVDA PSPLTPASSC RYDSSLSLLT KKFIALIKHA 120 EDGELDLNMA ADTLQVQKRR IYDITNVLEG IGLIEKKLKN RIHWKGLDPS RPGDMDKDGT 180 LLHAEIENLS MEEKCLDERI RQMQEKLRDY SEEKNNQRWL FVTEDDIKTL PCFQNETLIA 240 IKAPHGTTLE VPDPDEEKFD EMNGVDNSTN FPIASSSGSH ENLAVQGSPL AHAPPQIETH 300 TRESHEINSV YDSSQEYPGG MTKIIPSNID NDADYWLLSD ADISITDMWK TDSGVEWNDV 360 NMLQEELEMA GISTPRAHVP SSGVDNEQPR SCKKYPDVGT LLENLQNSLQ RINLQKHGLC 420 DPDVCELM

Sequence ? help Back to Top

Protein Sequence Length: 428 aa Download sequence Send to blast

MVYSPTTFVL ICNAHADFNV QIGISQPFKR KNGYQNNEVE SSELTASQAY SDIANSPFRT  60
PVAKGRANCR SKATKNNRSA PSTPISSVDA PSPLTPASSC RYDSSLSLLT KKFIALIKHA  120
EDGELDLNMA ADTLQVQKRR IYDITNVLEG IGLIEKKLKN RIHWKGLDPS RPGDMDKDGT  180
LLHAEIENLS MEEKCLDERI RQMQEKLRDY SEEKNNQRWL FVTEDDIKTL PCFQNETLIA  240
IKAPHGTTLE VPDPDEEKFD EMNGVDNSTN FPIASSSGSH ENLAVQGSPL AHAPPQIETH  300
TRESHEINSV YDSSQEYPGG MTKIIPSNID NDADYWLLSD ADISITDMWK TDSGVEWNDV  360
NMLQEELEMA GISTPRAHVP SSGVDNEQPR SCKKYPDVGT LLENLQNSLQ RINLQKHGLC  420
DPDVCELM

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-25	96	169	2	76	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011094221.1	0.0	transcription factor E2FA
Swissprot	Q9FNY0	1e-108	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A4D9AXF6	0.0	A0A4D9AXF6_SALSN; Uncharacterized protein
STRING	Migut.J00719.1.p	1e-171	(Erythranthe guttata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]