PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Ote100136550091

Organism

Ocimum tenuiflorum

Taxonomic ID

204149

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum

Family

E2F/DP

Protein Properties

Length: 371aa MW: 41032.6 Da PI: 4.5508

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Ote100136550091	genome	OteDB	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.6	1.8e-27	94	159	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Ote100136550091\|100136550091 94 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKIKNRIQWKG 159 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.8E-29	92	161	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	7.4E-35	94	159	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.09E-17	94	157	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.2E-24	96	159	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	4.71E-33	173	276	No hit	No description
Pfam	PF16421	2.5E-33	176	274	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	1.02E-41	187	276	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 371 aa Download sequence Send to blast
MKHINPLCEN LRENSLETLK RKPGVTGSEV EPSDHNAGPG NIAHVTGPFQ TPPSAKSGKL 60 QKAPKAKANK VSLIAMTNVG SPSGNNLTPV GPCRYDSSLG LLTKKFINLI KHAEDGILDL 120 NKAADTLEVQ KRRIYDITNV LEGIGLIEKK IKNRIQWKGL DVSKPGEVDE SLPGIQEEIE 180 NLNIEERKLD ERIREMQEKL RGLSEDENNQ RWLFVTEEDI KCLPCFQNET LIAIKAPHGT 240 TLEVPDPDEA VDYPQRRYRI VLRSTMGPID VYLVSQFEEN FEEINAVEEQ ACIPETPSAN 300 NNTSAPSSRL EIGGDETAAQ GVETQRMCSE ASTSQDFVSG ILKIVPEVDS DADYWLLSDA 360 DXXXXXXTCG A

Sequence ? help Back to Top

Protein Sequence Length: 371 aa Download sequence Send to blast

MKHINPLCEN LRENSLETLK RKPGVTGSEV EPSDHNAGPG NIAHVTGPFQ TPPSAKSGKL  60
QKAPKAKANK VSLIAMTNVG SPSGNNLTPV GPCRYDSSLG LLTKKFINLI KHAEDGILDL  120
NKAADTLEVQ KRRIYDITNV LEGIGLIEKK IKNRIQWKGL DVSKPGEVDE SLPGIQEEIE  180
NLNIEERKLD ERIREMQEKL RGLSEDENNQ RWLFVTEEDI KCLPCFQNET LIAIKAPHGT  240
TLEVPDPDEA VDYPQRRYRI VLRSTMGPID VYLVSQFEEN FEEINAVEEQ ACIPETPSAN  300
NNTSAPSSRL EIGGDETAAQ GVETQRMCSE ASTSQDFVSG ILKIVPEVDS DADYWLLSDA  360
DXXXXXXTCG A

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	6e-27	89	160	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011090314.1	0.0	transcription factor E2FB isoform X1
Swissprot	Q9FV71	1e-131	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A4D9AN86	0.0	A0A4D9AN86_SALSN; Uncharacterized protein
TrEMBL	A0A4D9BWW9	0.0	A0A4D9BWW9_SALSN; Uncharacterized protein
STRING	Migut.N02463.1.p	0.0	(Erythranthe guttata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]