PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PGSC0003DMP400006749
Organism
Solanum tuberosum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family E2F/DP
Protein Properties Length: 401aa    MW: 44378.9 Da    PI: 6.5855
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PGSC0003DMP400006749genomePGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP78.85.1e-25140205171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                           r+++sL+llt+kf+ ll+++++g+++ln+ a+ L   +v   +RRiYDi+NVLe+++liek+ k++irwkg
  PGSC0003DMP400006749 140 RYDNSLGLLTKKFIGLLQEADDGTLDLNHSAEVL---EV--AKRRIYDITNVLEGIGLIEKTTKSRIRWKG 205
                           689*******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.8E-25140206IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.14E-15140203IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.5E-30140205IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-22142205IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.11E-35216322No hitNo description
SuperFamilySSF1440743.14E-23217321No hitNo description
PfamPF164217.1E-22221319IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000902Biological Processcell morphogenesis
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0042023Biological ProcessDNA endoreduplication
GO:0051782Biological Processnegative regulation of cell division
GO:0005667Cellular Componenttranscription factor complex
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 401 aa     Download sequence    Send to blast
MSTTAGENVD LNLSLATPLH LRSSSSPSAI AVTASSPYRS HPRFLSNLCS ESLSVVPGNP  60
RPSATFGFAP KNEIEKSEEY NCGYGVSQRS PASNYSPLEQ APSAHTKQPS KRKSSRDTIE  120
ATKGINADLH DNLNLGVTYR YDNSLGLLTK KFIGLLQEAD DGTLDLNHSA EVLEVAKRRI  180
YDITNVLEGI GLIEKTTKSR IRWKGFRSTK SQGLDNQVST LKGEIGYLSA EDRRLDCCIR  240
EKLEQIRTLE SDVNCQKRLF LTEEDIRRLP HFRDKTLIAI KAPYASSIEV PDPCEDVDLE  300
RQYKLILRST TGPIDLFLLS KQGRQHEDIT VKHEKPLDAV SAAKKMDDAC PSPVHPCSLD  360
STASKLSGVH KIVPSHNSID DDYWLRSEEE VSATALWGIE *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-22136206374PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPGSC0003DMP400006749
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006342039.20.0PREDICTED: transcription factor E2FC
SwissprotQ9FV701e-75E2FC_ARATH; Transcription factor E2FC
TrEMBLM0ZWS10.0M0ZWS1_SOLTU; Uncharacterized protein
STRINGPGSC0003DMT4000096820.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA126252022
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.24e-78E2F/DP family protein
Publications ? help Back to Top
  1. Xu X, et al.
    Genome sequence and analysis of the tuber crop potato.
    Nature, 2011. 475(7355): p. 189-95
    [PMID:21743474]
  2. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  3. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  4. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]