PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PGSC0003DMP400042307
Common NameLOC102579077
Organism
Solanum tuberosum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family E2F/DP
Protein Properties Length: 387aa    MW: 43523.3 Da    PI: 9.2175
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PGSC0003DMP400042307genomePGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.71.9e-231782171
               E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                          rk+ksL+ll+++fl+l+ ++  +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  PGSC0003DMP400042307 17 RKQKSLGLLCSNFLSLYDREGVETIGLDDAARRL---GV--ERRRIYDIVNVLESIGVLARKAKNRYSWKG 82
                          79*****************999************...**..****************************98 PP
2E2F_TDP74.79.3e-24153233171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                           r+eksL+lltq+f+kl+ +++ ++++l+e+ak L+ +      +++k+RR+YDi+NVL++++ iek     ++k+++rw g
  PGSC0003DMP400042307 153 RREKSLGLLTQNFVKLFLCTNVDMICLDEAAKILLGDgrppaMTRTKVRRLYDIANVLSSMRYIEKthhpdTRKPAFRWLG 233
                           689**************************************99999************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.6E-261383IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.9E-271782IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.36E-151780IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.8E-201882IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.2E-22149234IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.1E-30153233IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-17155233IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.08E-11155234IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 387 aa     Download sequence    Send to blast
MALASDPSKE SRSTYCRKQK SLGLLCSNFL SLYDREGVET IGLDDAARRL GVERRRIYDI  60
VNVLESIGVL ARKAKNRYSW KGLGAIPRTL EQLKEEGLKE NVSGFDGSSS AKSQGSDDDE  120
DDRDSNLITS SQTDKLSSNS GVNSAAPVKS ENRREKSLGL LTQNFVKLFL CTNVDMICLD  180
EAAKILLGDG RPPAMTRTKV RRLYDIANVL SSMRYIEKTH HPDTRKPAFR WLGLRGRSEY  240
KSVDAFCAIE SKKRVFGTEL TNTTIKRNRV ALPMDGISDE TTRKQLLTEV KCENMENDFH  300
IPKQEPGLTA SKKSYQFGPF APPTIPQAEV SEADRMKRVH DWESLASSYR PQYHNQALKD  360
LFAHYVEAWK SWYLEVAGKN PIQLIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-36172254228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapPGSC0003DMP400042307
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9755150.0HG975515.1 Solanum lycopersicum chromosome ch03, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006345001.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-121E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLM1C9N40.0M1C9N4_SOLTU; Uncharacterized protein
STRINGSolyc03g113760.2.10.0(Solanum lycopersicum)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-123DP-E2F-like 1
Publications ? help Back to Top
  1. Xu X, et al.
    Genome sequence and analysis of the tuber crop potato.
    Nature, 2011. 475(7355): p. 189-95
    [PMID:21743474]
  2. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]