PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PK26582.1
Organism
Cannabis sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Cannabis
Family bHLH
Protein Properties Length: 239aa    MW: 26849 Da    PI: 7.4124
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PK26582.1genomeCCBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH34.44.1e-114588755
               HHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
        HLH  7 erErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
               + ErrRR r+++++  Lr+l+P+      +K++Ka+i+  Av Y+++Lq
  PK26582.1 45 ISERRRRGRMKEKLYALRSLVPNI-----TKMDKASIVGDAVLYVQDLQ 88
               67*********************7.....7******************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088815.0913887IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.62E-1640110IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.06E-104090No hitNo description
Gene3DG3DSA:4.10.280.101.2E-1640108IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.6E-144493IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.1E-84588IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0034756Biological Processregulation of iron ion transport
GO:0071281Biological Processcellular response to iron ion
GO:0071369Biological Processcellular response to ethylene stimulus
GO:0071732Biological Processcellular response to nitric oxide
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 239 aa     Download sequence    Send to blast
XRSENDNGDE DDDDDDDSSG TTTTTTTTPN ASSKRPKVDR SRTLISERRR RGRMKEKLYA  60
LRSLVPNITK MDKASIVGDA VLYVQDLQTQ SKKLKAEIAS LEASLEEVER YQTGSTTHKS  120
NTNIKDVKTN DSLAKMKIIT QMDMFQVEEK GFYVKVVCNK GEKAAISLYK ALESLTNFNI  180
KSSNLATVSD TFVLTFTLNV LINKECHDQR EPMNLPNLKL WVTGAFINQG FELNTATPF
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A4e-13461081274Transcription factor MYC2
5gnj_B4e-13461081274Transcription factor MYC2
5gnj_E4e-13461081274Transcription factor MYC2
5gnj_F4e-13461081274Transcription factor MYC2
5gnj_G4e-13461081274Transcription factor MYC2
5gnj_I4e-13461081274Transcription factor MYC2
5gnj_M4e-13461081274Transcription factor MYC2
5gnj_N4e-13461081274Transcription factor MYC2
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply. {ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:16117851}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: In roots by iron deficiency. Repressed by cytokinins. Induced by cold, UV, ethylene (ACC), jasmonic acid (JA), flagellin, and salicylic acid (SA) treatments. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15531708, ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:18397377}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024031455.11e-101transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
SwissprotQ0V7X44e-82FIT_ARATH; Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
TrEMBLA0A2P5FTK31e-110A0A2P5FTK3_TREOI; Basic helix-loop-helix transcription factor
STRINGXP_010111848.15e-99(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36793358
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G28160.17e-58FER-like regulator of iron uptake
Publications ? help Back to Top
  1. Schmid NB, et al.
    Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis.
    Plant Physiol., 2014. 164(1): p. 160-72
    [PMID:24246380]
  2. Doustaly F, et al.
    Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots.
    Metallomics, 2014. 6(4): p. 809-21
    [PMID:24549117]
  3. Le CT, et al.
    ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) Interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) Linking Iron Deficiency and Oxidative Stress Responses.
    Plant Physiol., 2016. 170(1): p. 540-57
    [PMID:26556796]
  4. Yang L, et al.
    Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis.
    Front Plant Sci, 2016. 7: p. 112
    [PMID:27014280]
  5. Zhou C, et al.
    Paenibacillus polymyxa BFKC01 enhances plant iron absorption via improved root systems and activated iron acquisition mechanisms.
    Plant Physiol. Biochem., 2016. 105: p. 162-173
    [PMID:27105423]
  6. Mai HJ,Pateyron S,Bauer P
    Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks.
    BMC Plant Biol., 2016. 16(1): p. 211
    [PMID:27716045]
  7. Zhou C, et al.
    Exogenous Melatonin Improves Plant Iron Deficiency Tolerance via Increased Accumulation of Polyamine-Mediated Nitric Oxide.
    Int J Mol Sci, 2017.
    [PMID:27792144]
  8. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  9. Naranjo-Arcos MA, et al.
    Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.
    Sci Rep, 2017. 7(1): p. 10911
    [PMID:28883478]
  10. Kailasam S,Wang Y,Lo JC,Chang HF,Yeh KC
    S-Nitrosoglutathione works downstream of nitric oxide to mediate iron-deficiency signaling in Arabidopsis.
    Plant J., 2018. 94(1): p. 157-168
    [PMID:29396986]
  11. Cui Y, et al.
    Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis.
    Mol Plant, 2018. 11(9): p. 1166-1183
    [PMID:29960107]