PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PSME_00039404-RA
Organism
Pseudotsuga menziesii
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Acrogymnospermae; Pinidae; Pinales; Pinaceae; Pseudotsuga
Family bHLH
Protein Properties Length: 458aa    MW: 51292.3 Da    PI: 5.9404
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PSME_00039404-RAgenomePRSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH391.4e-12247298155
                       CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
               HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                       +r++h ++Er+RR+++N+ ++ Lr+l+P +   + ++ + a+i   A++++k+L+
  PSME_00039404-RA 247 QRMTHIAVERNRRKQMNEHLSVLRSLMPGS---YIQRGDQASIIGGAIDFVKELE 298
                       79****************************...9******************995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000833.32E-14245302No hitNo description
PROSITE profilePS5088815.777246297IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.83E-16246310IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.109.6E-14247310IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000108.2E-10247298IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.9E-10252303IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS516718.719382458IPR002912ACT domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008152Biological Processmetabolic process
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 458 aa     Download sequence    Send to blast
MVLEALNSQV FNGTNLNQSS HEAGFVEMLH YPAERTGMTF LQMLDGIAVN RDGGIRSFAD  60
DIEEKLAASE QLDIKEQRPW QHGFQQLLNF PLCHQIDDSA FMMPPEFQNQ HATQYVPKIS  120
SGSVDNNNQS HDFQQARIHH HQQLFEPESC ITHVSESCSP IKTEACKDHS SSEAIEEGVS  180
SAARDPNSCI TANSSSENGT GGGFVTSSMM PSSTAPSSQL STRMEVRDRR KRKRSKACKN  240
SEEVESQRMT HIAVERNRRK QMNEHLSVLR SLMPGSYIQR GDQASIIGGA IDFVKELEQL  300
LQSLQAQKRK RDCEEFGCSP NSPTPFNGFF LSPQYTSYSA QWNSRYAVDK TNSFNDTGNE  360
LIAENRSAVA DIEVTMIETH ASIKILSLKR PGQLMKTIDA LQRLRMTILH LNITTIDQTV  420
LYSFNVKIED ECLLTSADEI ATAVHEIFTI IHSNNANN
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1228233RRKRKR
2247258RMTHIAVERNRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEF6766590.0EF676659.1 Picea sitchensis clone WS02746_J09 unknown mRNA.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020532224.11e-110transcription factor bHLH94 isoform X5
SwissprotQ56YJ82e-71FAMA_ARATH; Transcription factor FAMA
TrEMBLB8LLL60.0B8LLL6_PICSI; Uncharacterized protein
STRINGERM966271e-109(Amborella trichopoda)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-60bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]