PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Pbr011800.1

Organism

Pyrus bretschneideri

Taxonomic ID

225117

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Pyrus

Family

E2F/DP

Protein Properties

Length: 419aa MW: 46163.6 Da PI: 4.4488

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Pbr011800.1	genome	CPETR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.4	2.1e-27	96	161	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r ++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Pbr011800.1 96 RFDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 161 6789****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.7E-29	94	163	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	5.03E-17	96	159	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.1E-34	96	161	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.0E-24	98	161	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	2.3E-32	173	278	No hit	No description
CDD	cd14660	1.73E-47	176	278	No hit	No description
Pfam	PF16421	4.4E-32	177	276	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 419 aa Download sequence Send to blast
MNNNWFSLIG IGVYFSAVLK RKSDAVDCEA ESTDRTTAPG YTEVANIPLQ TPVANKVGRA 60 NKASRLTKCS KSGPQTPASN VGSPSGANVT PAGPCRFDSS LGLLTKKFIN LIKHAEDGIL 120 DLNKAADTLE VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GLDVSRTGDA DENYPSLQAQ 180 VEGLSTEERR LDQQIREMQE RLRDLSDDES NKKWLFVTEE DIKGLPSLQN ETLIAIKAPH 240 GTTLEVPDPD EAVDYPQRRY RMLLRSTMGP IDVYLVSQFE EKFEEINGVE VPTNIPSTSW 300 ANENPAATMV AEDRGKDVEM QVPDDHRMSA DPTAAQDFTS GIMKIVPSDV DSDADYWLLS 360 DADISITDIW RTEPGVVWND LGALDQDYPL VNASSPRPQT PPSSLIEVPS TTSNPTKT*

Sequence ? help Back to Top

Protein Sequence Length: 419 aa Download sequence Send to blast

MNNNWFSLIG IGVYFSAVLK RKSDAVDCEA ESTDRTTAPG YTEVANIPLQ TPVANKVGRA  60
NKASRLTKCS KSGPQTPASN VGSPSGANVT PAGPCRFDSS LGLLTKKFIN LIKHAEDGIL  120
DLNKAADTLE VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GLDVSRTGDA DENYPSLQAQ  180
VEGLSTEERR LDQQIREMQE RLRDLSDDES NKKWLFVTEE DIKGLPSLQN ETLIAIKAPH  240
GTTLEVPDPD EAVDYPQRRY RMLLRSTMGP IDVYLVSQFE EKFEEINGVE VPTNIPSTSW  300
ANENPAATMV AEDRGKDVEM QVPDDHRMSA DPTAAQDFTS GIMKIVPSDV DSDADYWLLS  360
DADISITDIW RTEPGVVWND LGALDQDYPL VNASSPRPQT PPSSLIEVPS TTSNPTKT*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-26	91	162	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Pbr011800.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009374797.1	0.0	PREDICTED: transcription factor E2FB-like, partial
Swissprot	Q9FV71	1e-144	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A498IMT0	0.0	A0A498IMT0_MALDO; Uncharacterized protein
STRING	XP_009374797.1	0.0	(Pyrus x bretschneideri)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-146	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]